CXCR4 and CCR7 Expression in Primary Nodal Diffuse Large B-Cell Lymphoma-A Clinical and Immunohistochemical Study.

CONCLUSIONS: There is a positive correlation between CXCR4 overexpression and BM involvement. CXCR4 and CCR7 overexpression is associated with poorer overall survival, especially in CXCR4 and CCR7 copositive patients. CXCR4, CCR7, Ki-67 index, and MYC were independent prognostic factors for DLBCL. Blocking CXCR4 and/or CCR7 can be a novel therapeutic strategy for DLBCL.
PMID: 30904045 [PubMed - in process]

Source: The American Journal of the Medical Sciences - March 26, 2019 Category: General Medicine Authors: Du H, Zhang L, Li G, Liu W, Tang W, Zhang H, Luan J, Gao L, Wang X Tags: Am J Med Sci Source Type: research