LMP1 and 2A Induce the Expression of Nrf2 Through Akt Signaling Pathway in Epstein-Barr Virus-Transformed B Cells.

In conclusion, our study demonstrates that Nrf2 promotes proliferation of EBV-transformed B cells through the EBV-related proteins LMP1 and 2A and Akt signaling, implicating Nrf2 as a potential molecular target for EBV-associated disease.
PMID: 30909091 [PubMed - as supplied by publisher]

Source: Translational Oncology - March 21, 2019 Category: Cancer & Oncology Authors: Yun SM, Kim YS, Hur DY Tags: Transl Oncol Source Type: research