Yield of Malignant Pleural Effusion for Detection of Oncogenic Driver Mutations in Lung Adenocarcinoma

Conclusion: Genetic mutation analysis can be performed on malignant pleural effusions secondary to lung adenocarcinoma, independent of fluid volume.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research

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Conclusions: We found that the use of the hybrid applicator allowed for adequate target coverage in a patient with unusual anatomy. The patient tolerated treatment well and demonstrated favorable response on follow-up exam and imaging. The long-term curative result needs to be further evaluated. PMID: 31435436 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Conclusions: The hybrid inverse optimization method achieved high conformity in the clinical practice. The non-coplanar needle can help to achieve a better dose distribution than the coplanar needle. PMID: 31435434 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Adenocarcinoma of the prostate is a major health concern in the United States, with 31,620 deaths estimated for 2019.1 A recent population-based study of nearly 400,000 patients found that radical prostatectomy (RP) was the most commonly utilized treatment in the United States for intermediate- and high-risk patients.2 In men under aged 70 in these risk groups, RP accounted for 48%-82% of first line therapy.2 These patients with intermediate- and high-risk disease represent the population most to be at high risk for recurrence following RP, historically defined by the presence of extracapsular extension, seminal vesicle in...
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Purpose: A common diagnostic dilemma in the assessment of small pulmonary nodules on computed tomography (CT) is in distinguishing benign intrapulmonary lymph nodes (IPLNs) from small primary pulmonary malignancies. Several CT features have been described of IPLNs, including attachment to a pleural surface. We had observed that IPLNs were often connected to a pulmonary vein and sought to evaluate the utility of this sign in discriminating IPLNs from lung adenocarcinomas. The frequency of other previously described CT signs of IPLNs was also compared with lung adenocarcinomas. Materials and Methods: We retrospectively ...
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Original Articles Source Type: research
ConclusionCLE is a useful tool for prediction of histology to assess the polypoidal lesions of the GI tract, and it may avoid polypectomy at least in some patients.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Invasive mucinous adenocarcinoma (IMA) is a variant of lung adenocarcinoma [1]. The tumor cells in IMA are columnar and contain abundant intracytoplasmic mucin, mimicking goblet cells of the colon [1]. IMA is often positive for HNF4-alpha, but negative for TTF-1 [1]. IMA reveals genetic abnormalities similar to those of colorectal carcinoma and commonly shows KRAS mutation (in up to 90% of cases) [1,2].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
ConclusionThis study used algorithmic detectability index to assess task-based image equality for detecting hepatic lesions and validated it against observer rankings on standard-of-care clinical CT cases. Our study indicates that detectability index provides a robust reflection of overall image quality for detecting hepatic lesions under clinical CT imaging conditions. This demonstrates the concept of utilizing the measure to quantitatively assess the quality of the information content that different imaging conditions can provide for the same clinical imaging task, which enables targeted optimization of clinical CT syste...
Source: Academic Radiology - Category: Radiology Source Type: research
ConclusionThe iodine quantification parameters derived from enhanced DE-CT during the VP may be useful for distinguishing lung squamous cell carcinoma from adenocarcinoma.
Source: Academic Radiology - Category: Radiology Source Type: research
Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy. Oncol Rep. 2019 Aug 13;: Authors: Zhou X, Liao X, Wang X, Huang K, Yang C, Yu T, Liu J, Han C, Zhu G, Su H, Qin W, Han Q, Liu Z, Huang J, Gong Y, Ye X, Peng T Abstract The present study aimed to determine the clinical significance and potential molecular mechanisms of C‑C motif chemokine receptor (CCR) genes in patients with early‑stage pancreatic ductal adenocarcinoma (PDAC). The transcriptomic, survival and clin...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
EMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. Oncol Rep. 2019 Aug 20;: Authors: Wang L, Jin J, Zhou Y, Tian Z, He B, Huang Y, Ding F Abstract Esophageal adenocarcinoma (EAC) is an aggressive and challenging disease to treat, with an overall five‑year survival rate of
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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