Coupling tumor growth and bio distribution models.

Coupling tumor growth and bio distribution models.
Biomed Microdevices. 2019 Mar 25;21(2):33
Authors: Santagiuliana R, Milosevic M, Milicevic B, Sciumè G, Simic V, Ziemys A, Kojic M, Schrefler BA
Abstract
We couple a tumor growth model embedded in a microenvironment, with a bio distribution model able to simulate a whole organ. The growth model yields the evolution of tumor cell population, of the differential pressure between cell populations, of porosity of ECM, of consumption of nutrients due to tumor growth, of angiogenesis, and related growth factors as function of the locally available nutrient. The bio distribution model on the other hand operates on a frozen geometry but yields a much refined distribution of nutrient and other molecules. The combination of both models will enable simulating the growth of a tumor in a whole organ, including a realistic distribution of therapeutic agents and allow hence to evaluate the efficacy of these agents.
PMID: 30906958 [PubMed - in process]

Source: Biomedical Microdevices - March 24, 2019 Category: Biomedical Engineering Authors: Santagiuliana R, Milosevic M, Milicevic B, Sciumè G, Simic V, Ziemys A, Kojic M, Schrefler BA Tags: Biomed Microdevices Source Type: research