Serum Cobalamin and Folate Concentrations in Common Marmosets (Callithrix jacchus) with Chronic Lymphocytic Enteritis.

Serum Cobalamin and Folate Concentrations in Common Marmosets (Callithrix jacchus) with Chronic Lymphocytic Enteritis. Comp Med. 2019 Mar 22;: Authors: Parambeth JC, Ross CN, Miller AD, Austad SN, Lidbury JA, Suchodolski JS, Steiner JM Abstract Serum cobalamin and folate concentrations can serve as surrogate markers of gastrointestinal disease in dogs and cats, wherethey can have diagnostic, therapeutic, and prognostic implications. Chronic disease of the gastrointestinal tract, particularly chronic lymphocytic enteritis (CLE), occurs frequently in captive common marmosets. The aims of this study were to validate a commercially available assay for measuring serum cobalamin and folate concentrations in common marmosets, to establish reference intervals for these analytes in healthy marmosets, and to measure serum concentrations in common marmosets with CLE. The commercial assay was linear, accurate, precise, and reproducible for the measurement of serum cobalamin and folate concentrations in common marmosets. In healthy marmosets, the serum cobalamin concentration ranged from 322 to2642 pg/mL (n = 35) and serum folate concentration from 54.8 to 786.4 ng/mL (n = 37). Low serum folate concentrations weremoderately sensitive (greater than 70%) for CLE, and low serum cobalamin concentrations were moderately (greater than70%) specific for CLE. Both serum cobalamin and folate concentrations were relatively unchanged in marmosets during 120t...
Source: Comparative Medicine - Category: Zoology Authors: Tags: Comp Med Source Type: research