Africa: Tackling River Blindness in a Country Ravaged By Ebola

[Thomson Reuters Foundation] There were lots of people suffering, needing help, but there was also fear. People were slow to trust.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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Conclusions: Two novel G22S mutations of Cx46 and Cx50 were identified, and preliminary functional analysis revealed a potential deleterious effect of these mutations due to the malfunction of connexins. Abbreviations: ADCC: autosomal dominant congenital cataract; Cx26: connexin26; Cx32: connexin32; Cx46: connexin46; Cx46WT: wild-type connexin46; Cx50: Connexin50; Cx50WT: wild-type connexin50; DAPI: 4',6-diamidino-2-phenylindole; EGFP: enhanced green fluorescent protein; FBS: fetal bovine serum; GJA-:gap junction alpha-; PCR: polymerase chain reaction; PolyPhen: polymorphism phenotyping; PSIC: position-specific independent...
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
Elevated intraocular pressure (IOP) due to insufficient aqueous humor outflow through the trabecular meshwork and Schlemm's canal (SC) is the most important risk factor for glaucoma, a leading cause of blindness worldwide. We previously reported loss of function mutations in the receptor tyrosine kinase TEK or its ligand ANGPT1 cause primary congenital glaucoma in humans and mice due to failure of SC development. Here, we describe a novel approach to enhance canal formation in these animals by deleting a single allele of the gene encoding the phosphatase PTPRB during development. Compared toTek haploinsufficient mice, whic...
Source: eLife - Category: Biomedical Science Tags: Developmental Biology Human Biology and Medicine Source Type: research
AbstractPurposeImproved therapies for pediatric central nervous system (CNS) tumors have increased survival rates; however, many survivors experience significant long-term functional limitations. Survivors of pediatric CNS tumors can experience deficits in social attainment. The aim of this review was to systematically amalgamate findings pertaining to social attainment (i.e., educational attainment, marriage, employment outcomes) in survivors of pediatric CNS tumors.MethodsPubMed (web-based), PsycINFO (EBSCO), EMBASE (Ovid), and Web of Science (Thomson Reuters) were used to identify articles published between January 2011...
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
We describe the functional reorganisation and associated structural and connectivity changes that occur in the brain of those affected by the condition. By considering animal models of this condition, we investigate the changes that may be occurring on a scale that is not captured by human in vivo imaging techniques. Finally, we lay out a model pathway for taking auditory information to the occipital cortex that may be specific to anophthalmia.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
This week, investigating child mortality rates at a local level, and building genes from non-coding DNA.In this episode:00:43 A regional view of childhood mortalityResearchers map countries' progress towards the UN’s Sustainable Developmental Goals. Research Article: Burstein et al.; World View: Data on child deaths are a call for justice; Editorial: Protect the census07:22 Research HighlightsAstronomers identify a second visitor from beyond the solar system, and extreme snowfall stifles animal breeding in Greenland. Research Highlight: The comet that came in from interstellar ...
Source: Nature Podcast - Category: Science Authors: Source Type: podcasts
Publication date: Available online 15 October 2019Source: Journal of Molecular BiologyAuthor(s): Laura Jo Sherwood, Alexander Bryan Taylor, Peter John Hart, Andrew HayhurstAbstractWe had previously shown that three anti-Marburgvirus nanobodies (VHH or sdAb) targeted a cryptotope within an alpha-helical assembly at the nucleoprotein (NP) C-terminus that was conserved through half a century of viral evolution. Here, we wished to determine whether an anti-Ebola virus sdAb, that was cross-reactive within the Ebolavirus genus, recognized a similar structural feature upstream of the ebolaviral NP C-terminus. Additionally, we sou...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
[Nyasa Times] A 37-year-old man initially suspected to have ebola has died of high fever in quarantine in Karonga and authorities maintain this was not an ebola case.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Premium Times] Dapo Olorunyomi, publisher of PREMIUM TIMES, has called for a special honour for late Stella Adadevoh, for her bravery that warded off the dreaded Ebola epidemic from Nigeria.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Nyasa Times] Health experts in Karonga have finally cleared a 37-year-old man of ebola, ending day of heightened fears and speculations in the border district.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
This article is part of HuffPost’s Project Zero campaign, a yearlong series on neglected tropical diseases and efforts to fight them. KINSHASA, Congo ― In early 2014, few people worried that the Ebola virus, which is up to 90 percent fatal, would pose a global threat. So the World Health Organization sent shockwaves around the world when it announced that Ebola was spreading out of control in West Africa. Before the epidemic was over two years later, it had killed thousands of people. They died in terrifying and painful ways, often passing the disease on to family members before and even after death....
Source: Science - The Huffington Post - Category: Science Source Type: news
More News: African Health | Blindness | Ebola | Opthalmology | River Blindness