ROS-responsive thioether-based nanocarriers for efficient pro-oxidant cancer therapy

This study demonstrates that ROS-responsive TEP NPs are effective drug carriers for efficient intracellular delivery of hydrophobic drug, PL.Graphical abstractROS-responsive thioether-bearing polymers (TEP) were synthesized and used as drug carriers for intracellular delivery of piperlongumine (PL) in cancer cells. The PL-loaded TEP nanoparticles exhibited ROS-triggered disassembly in cancer cells, leading to efficient cancer cell-specific apoptosis.
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research