Pharmaceutical Paroxetine-based organic salts of carboxylic acids with optimized properties. The identification and characterization of a potential novel API solid forms

CrystEngComm, 2019, Accepted Manuscript DOI: 10.1039/C8CE02076K, PaperPaulo de Sousa de Sousa Carvalho, Jr., Luan Farinelli Diniz, Juan Carlos Tenorio Clavijo, Matheus S. Souza, Chris Hebert Jesus Franco, Rafael C. Rial, Karla Regina Warszawski, Carlos E. D. Nazario, Javier A Ellena Paroxetine hydrochloride, PRX HCl, is an important and widely prescribed antidepressant drug for anxiety and depression treatment. Since hydrochloride salt can imply problems in its manufacture, we have designed organic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - Category: Chemistry Authors: Source Type: research

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Conclusions/Importance: The current findings provide evidence that specific classes of motives were not only associated with marijuana use frequency and problems but other risk and protective factors, such as anxiety sensitivity and social support. PMID: 31017512 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
CASE: Peter is a 26-year-old group home resident in Austria with a history of poor peer relationships, including being bullied, and previous diagnoses of attention-deficit hyperactivity disorder, Asperger syndrome, social anxiety, depression, and developme...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Young Adults Source Type: news
Publication date: Available online 25 April 2019Source: Brain, Behavior, and ImmunityAuthor(s): Richard Whale, Renata Fialho, Andy P. Field, Graham Campbell, Jeremy Tibble, Neil A. Harrison, Michael RoltAbstractThe discovery that prolonged administration of interferon-alpha (a pro-inflammatory cytokine) readily precipitates depressive symptoms has played a key role in development of the inflammation theory of major depressive disorder (MDD). However, it remains unclear whether the clinical phenotype of patients with inflammation-associated depression significantly overlaps with, or can be distinguished from that of patient...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
This study included 17581 women who had had an induced abortion and 17581 women who had had a live birth. Within 10 years of the index date, 6.7% of the participants with induced abortions and 5.4% of those with live births were diagnosed with depression (log-rank p-value = 0.003). The respective figures were 3.4% and 2.7% for anxiety disorder (log-rank p-value = 0.255), 6.2% and 5.6% for adjustment disorder (log-rank p-value = 0.116), and 19.3% and 13.3% for somatoform disorder (log-rank p-value
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Avoiding antidepressants has its benefits, says psychiatrist Professor Madhukar Trivedi. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Depression subscribers-only Source Type: blogs
When you are raised in a narcissistic family it can feel like there is no help. Parents who are narcissistic are often self-focussed. They will relate to their children as “self-adjuncts” serving to support them and their image of themselves. Do something that reflects well on them and you are suddenly the Golden Child. Make a mistake, ask for help or express your vulnerability, and you are on your own or worse, ridiculed. Children in this situation learn quickly that their needs are unwelcome. Because they are raised to ignore, undermine or suppress their natural sense of who they are, they become ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anger Family Narcissism Relationships Self-Esteem Trauma abuse Addiction Childhood Trauma chronic shame Codependence Complex trauma Domestic Violence Emotional Abuse Narcissistic Personality Disorder Projection Unhealthy Bo Source Type: blogs
Americans are some of the most stressed-out people in the world, according to Gallup’s annual Global Emotions report. For the report, Gallup polled about 1,000 adults in countries around the world last year about the emotions they’d experienced the day before the survey. Negative emotions and experiences — stress, anger, worry, sadness and physical pain — were common around the world, tying 2017’s record-setting levels, the report found. In the U.S., 55% of respondents told Gallup they’d felt a lot of stress the day before, well above the global average of 35%. Gallup’s research fo...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Mental Health/Psychology onetime Source Type: news
In this study, we examined effects of CP2305 on top athletes experiencing physical and mental stresses. Forty-nine male university Ekiden (long distance relay race) runners daily took the CP2305-containing beverage for 12 weeks during training for and competing in All-Japan university championships. The CP2305 intake significantly facilitated recovery from fatigue and relieved anxiety and depressive mood, compared with placebo intake. The CP2305 intake significantly prevented the training-induced reduction of hemoglobin and facilitated exercise-induced increase in serum growth hormone levels. The CP2305 intake significan...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
 We all know what first aid is. Many of us even have first aid kits that we’ve purchased or put together ourselves. We pull them out when we have a minor injury and grab the bandages or whatever we need. But what about first aid for the mind? It’s not a kit you can pick up at the pharmacy, but there is mental health first aid that you can learn. Find out more about it in this episode.   Subscribe to Our Show! And Remember to Review Us! About Our Guest Michael Cox is a licensed professional counselor in the state of Texas and is the co-founder and therapist in private practice at Whole...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Mental Health and Wellness The Psych Central Show Gabe Howard mental health first aid Vincent M. Wales Source Type: blogs
Numerous studies have examined how alexithymia (difficulty identifying and describing one's emotions and a preference for externally oriented thinking) relates to chronic pain and associated disability. We conducted a systematic review and meta-analysis to summarize individual studies that either assessed alexithymia in individuals with chronic pain vs controls or related alexithymia to pain intensity, physical interference, depression, and anxiety. We searched MEDLINE, Embase, and PsycINFO from inception through June 2017; 77 studies met the criteria (valid assessment of alexithymia in adults or children with any chronic ...
Source: Pain - Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
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