Nucleic acid-based fluorescent methods for the determination of DNA repair enzyme activities: A review.
Nucleic acid-based fluorescent methods for the determination of DNA repair enzyme activities: A review.
Anal Chim Acta. 2019 Jul 04;1060:30-44
Authors: Lee CY, Kim H, Park KS, Park HG
Abstract
DNA repair pathways are closely associated with the maintenance of genomic integrity, disease outbreak, and the development of therapeutics. Owing to these significances, novel analytical methods for enzymes that are involved in the DNA repair pathways have been actively investigated. This review focuses on discussions on nucleic acid-based methods, especially those based on the fluorescence, for the determination of DNA repair enzymes. Furthermore, this review not only provides meaningful insights in creating ingenious fluorescent detection methods but it also suggests future directions that will be followed in developing new analytical technologies for the DNA repair enzymes.
PMID: 30902329 [PubMed - in process]
Source: Analytica Chimica Acta - Category: Chemistry Authors: Lee CY, Kim H, Park KS, Park HG Tags: Anal Chim Acta Source Type: research