The effect of neoadjuvant platinum-based chemotherapy in BRCA mutated triple negative breast cancers -systematic review and meta-analysis

ConclusionsThis meta-analysis shows that the addition of platinum to chemotherapy regimens in the neoadjuvant setting increases pCR rate inBRCA – mutated as compared to wild-type TNBC patients. However, this trend did not achieve statistical significance.Trial registrationCRD42018092341
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research