The Effect of Optimism and Connectedness on Psychological Adjustment of Children with Cancer and Comparison Peers

Conclusion: Findings suggest that patients with cancer are doing remarkably well with regard to adjustment. Connectedness with parents and peers mediates the relationship between optimism and psychological adjustment. As such, children with cancer who are identified as experiencing poor adjustment may benefit from interventions to foster connectedness.
Source: Journal of Developmental and Behavioral Pediatrics - Category: Child Development Tags: Original Articles Source Type: research

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The U.S. Food and Drug Administration approves a dozen cancer drugs every year, but the agency has greenlighted only six since 1978 specifically for childhood cancers. It’s not like adult cancers can always be repurposed for children at a lower dose. The causes of pediatric cancer are much different, and they generally have few mutations and occur when the normal development process is accentuated and inappropriately activated after birth. The National Cancer Institute estimated that more than…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
(Lund University) The most common form of childhood cancer is acute lymphoblastic leukaemia (ALL). Researchers at Lund University in Sweden, in cooperation with Karolinska Institutet, SciLifeLab and the University of Cambridge, have now carried out the most extensive analysis to date of ALL at the protein level, by studying the activity in over 8 000 genes and proteins. The results show aberrant folding in the DNA string, which in turn affects the genes' activity. The study was recently published in Nature Communications.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
This study describes current reimmunization practices among pediatric oncologists. We surveyed the Children’s Oncology Group (COG)-identified principle investigators to capture clinical practices among pediatric oncologists within their institutions regarding reimmunization of non–hematopoietic stem cell transplantation patients. The majority of respondents did not routinely assess vaccine-related immune status; those who did most frequently assessed 6 months after cessation of therapies. Methods of assessment included type of therapy received, vaccine titers, and absolute lymphocyte counts. Providers from smal...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Original Articles Source Type: research
Objectives: Fatigue is a common and disabling late effect in childhood cancer survivors (CCS). In this pilot study, the effectiveness of cognitive behavior therapy (CBT) in CCS with persistent and severe fatigue was retrospectively evaluated. Materials and Methods: In total, 33 consecutively referred CCS with persistent severe fatigue were offered CBT. The primary outcome was fatigue severity (Checklist Individual Strength, Fatigue Severity Subscale). Secondary outcomes were functional impairment, psychologic distress, and quality of life (QoL). Results: In total, 25 CCS completed CBT (76%). The mean age of CCS was...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Medical Progress Source Type: research
A 2-year-old Asian girl presented to our facility for the evaluation of thrombocytopenia. She was treated with intravenous immunoglobulin under the impression of immune thrombocytopenia. However, her body temperature spiked and progressive pancytopenia, hepatosplenomegaly, abnormal liver function, coagulopathy, and pulmonary infiltration developed. The final diagnosis was systemic Epstein-Barr virus (EBV)-positive T-cell lymphoma of childhood with hemophagocytic syndrome. This type of cancer is extremely rare but occurs more commonly in Asians. Its prognosis is generally poor, and a treatment strategy is yet to be establis...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Morphology Corner Source Type: research
Abstract OBJECTIVES: To explore the relationships among perceived stress, biomarkers of hypothalamic-pituitary-adrenal (HPA) activity, gonadotropin levels, and anti-Müllerian hormone (AMH) in female childhood cancer survivors (CCSs). SAMPLE & SETTING: 24 female CCSs from the Royal Hospital for Sick Children in Edinburgh, Scotland, were included in the study. METHODS & VARIABLES: Perceived stress was measured using the Perceived Stress Scale. HPA activity was measured using salivary cortisol and hair cortisol. Ovarian function was measured using serum gonadotropin levels and serum AMH levels....
Source: Oncology Nursing Forum - Category: Nursing Authors: Tags: Oncol Nurs Forum Source Type: research
This study provides definitive evidence and possible mechanisms of intra-familial phenotypic heterogeneity in VHL families, which is helpful to the update of surveillance guidelines. Introduction von Hippel-Lindau (VHL) disease (MIM 193300) is a rare autosomal dominant cancer syndrome caused by germline mutations in the VHL tumor suppressor gene (Latif et al., 1993; Lonser et al., 2003). Generally, the first VHL-related manifestation occurred in the third decade of patient’s life, and the penetrance is more than 90% by 70 years old (Ong et al., 2007; Nordstrom-O’brien et al., 2010). Patients may develop...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study, based on the whole-genome methylation datasets from The Cancer Genome Atlas (TCGA) and several machine learning methods, we evaluated the possibility of DNA methylation signatures for identifying lymph node metastasis of LUAD, differentiating between tumor tissue and normal tissue, and predicting the overall survival (OS) of LUAD patients. Using the regularized logistic regression, we built a classifier based on the 3616 CpG sites to identify the lymph node metastasis of LUAD. Furthermore, a classifier based on 14 CpG sites was established to differentiate between tumor and normal tissues. Using the Least Ab...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion: Taken together, lncRNA OIP5-AS1 acted as a ceRNA to drive proliferation, migration and invasion of HemECs through regulating miR-195-5p/NOB1 axis. Introduction Infant hemangioma (IH) is a benign neoplasm commonly seen in childhood, which is more common in premature infants and infants with low birth weight (Smith et al., 2017). There are three distinct clinical histological stages in IH: the early proliferative stage, when undeveloped blood vessels are rapidly growing; plateau stage and final regressive stage, with scattered capillaries and large drainage vessels (Csoma et al., 2017). IH is characterize...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Laia Gorchs1*, Carlos Fernández Moro1,2, Peter Bankhead3, Katharina P. Kern1, Imrul Sadeak1, Qingda Meng1, Elena Rangelova4,5 and Helen Kaipe1,6* 1Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden 2Department of Pathology/Cytology, Karolinska University Hospital, Stockholm, Sweden 3Division of Pathology, Centre for Genomic &Experimental Medicine, Western General Hospital, Institute of Genetics &Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 4Department of CLINTEC, Karolinska Institutet, Stockholm, Sweden 5Pancreatic Surgery Unit, Center for Digesti...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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