It ’s ‘time to #EndTB’, says UN on World Tuberculosis Day
Tuberculosis, or TB, is not only the world's top infectious killer, it is also the leading cause of deaths among people with HIV and a major cause of antimicrobial resistance-related deaths, the United Nations health agency said on Sunday, World Tuberculosis Day.
ConclusionWhole-Genome Sequencing ofMycobacterium tuberculosis offers the detection of drug resistance to all drugs in a single test and also provides insight into the evolution and drug-resistant tuberculosis.
ConclusionsResistant MTB isolates in Algeria harbor resistance genotypes similar as in other countries but some rare patterns may result from selection and transmission processes inherent to the country.
ConclusionTherefore, effective behavioural intervention and thorough investigation on ethnic disparities in tuberculosis treatment are needed to promote good compliance in order to achieve better treatment outcomes.
ConclusionsWe have observed worrying results regarding susceptibility to some drugs used as first-line agents in the treatment of diseases caused byM. kansasii.
Roche today announced the CE-IVD launch of the cobas ® MTB-RIF/INH test to detect resistance to antibiotics within tuberculosis DNA.
ConclusionOverexpression of EP genes can contribute to the emergence of a MDR phenotype in M. tuberculosis. Inhibition of EPs may provide a promising strategy for improving tuberculosis treatment outcomes in patients infected with M/XDR-TB isolates.
ConclusionsOur results clearly showed that efflux systems, besides spontaneous mutations, play a role in the development of INH/RIF resistance. In addition, although VP was effective in reducing the expression of some efflux pumps, it was not very successful at the phenotypic level.
[Vanguard] Drug-Resistant diseases caused by Antimicrobial Resistance, AMR, including multidrug-resistant tuberculosis, MDR-TB, respiratory tract infections, sexually transmitted infections, STIs and Urinary Tract Infections, UTIs, have become a major threat to life globally.
In this study, a BER homolog encoded by cj0595c (named nth) in C. jejuni was analyzed for endonuclease III activity and for its role in maintaining genomic stability. It was found that inactivation of nth resulted in elevated frequencies of spontaneous fluoroquinolone-resistant (FQR) and oxidative stress resistant (OXR) mutants, compared with the wild-type strain in C. jejuni. Sequencing analysis of the FQR and OXR mutants revealed that the elevated mutation rates were associated with C → T or G → A transition in gyrA (FQR mutants) or perR (for OXR mutants). In an in vitro assay, a purified recombinant C. jejuni ...
Abstract Mycobacterium tuberculosis is the leading cause of morbidity and mortality by infectious disease worldwide. The incredible disease burden combined with the long course of drug treatment and increasing incidence of antimicrobial resistance among M. tuberculosis isolates necessitates a need for both novel drugs and drug targets to treat this deadly pathogen. Recent work has produced several promising clinical candidates targeting components of the electron-transport chain (ETC) of M. tuberculosis, highlighting this pathway's potential as a viable drug target. Menaquinone is an essential component of the M. ...