Follow up on atopy and the gastrointestinal tract - a review of a common association 2018.

Follow up on atopy and the gastrointestinal tract - a review of a common association 2018. Expert Rev Gastroenterol Hepatol. 2019 Mar 22;: Authors: Walker MM, Talley NJ, Keely S Abstract INTRODUCTION: Primary atopic disorders can be classified as heritable genetic disorders presenting with deregulated pathogenic allergic effector responses irrespective of sensitization. In the last decade, there are parallel rises in the burden of atopic and gastrointestinal (GI) diseases. Areas covered: There is increasing recognition of an association between atopy and GI disease through immune dysregulation, the microbiome and shared genetic pathways. Since the first article on atopy and the GI tract in 2014 in this journal, many more studies have shed light on the shared pathways in these diseases, particularly in the field of eosinophilic GI disease, functional GI disorders and inflammatory bowel disease. Expert opinion: Understanding the links with common mechanisms in atopy and GI diseases that may lead to better targeting of treatment through manipulation of immune mechanisms, the microbiome, genetics, food allergens and specific GI diseases such as inflammatory bowel disease, functional GI disorders. PMID: 30900475 [PubMed - as supplied by publisher]
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

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Authors: Ribaldone DG, Pellicano R, Actis GC Abstract An increasing deal of attention is being conveyed on the extra-intestinal manifestations of inflammatory bowel diseases (IBD). We compiled the present review in an attempt to upgrade the accuracy of the classification of such polymorphic entities. We focused on three patterns. First, the conventional extra-intestinal manifestations localized to bone and joints, to the eye, to the biliary tree and to the skin. Second, the so-called IBD-like syndromes accompanied by bone marrow-derived anomalies of innate or acquired immunity. Third, specific disorders of the skin...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
We have read with great interest the recently published article by Pellet et  al.1 The authors assessed the efficacy and safety of calcineurin inhibitors as an induction therapy combined with vedolizumab as a maintenance therapy in a cohort of patients with steroid and anti–tumor necrosis factor–refractory ulcerative colitis (UC), using colectomy-free survival as the pr imary end point. Interestingly, this retrospective study identified the female sex, the presence of hemoglobin (Hb) greater than 11.2 g/dL, age, and concomitant immunosuppressant as baseline factors associated with colectomy.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
We read with great interest the article by Hanauer et  al.1 Their study showed that tofacitinib induction therapy for ulcerative colitis results in a rapid clinical response. We recently used tofacitinib and infliximab as combination rescue therapy to avoid colectomy in a hospitalized patient with severe ulcerative colitis. We also observed a very rap id onset of action.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Conventional imaging techniques accurately detect strictures in patients with Crohn's disease, but magnetic resonance enterography (MRE) best differentiates fibrotic from inflammatory components, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG. Introduction Papillary thyroid carcinoma (PTC), the main variant of differentiated thyroid carcinoma (DTC), is the most common thyroid cancer, accounting for 70–80% of all thyroid carcinomas and occurring predominantly in women, generally with a good prognos...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In conclusion, our study might provide evidence that GQD treats diarrhea maybe involved in modulating gut microbiota and increasing SCFA levels. Introduction Diarrheal diseases cause approximately 1.7 billion new infections and 0.76 million deaths in children of under 5 years of age annually and are thus the second most common cause of mortality in young children in developing countries (Kotloff et al., 2012, 2013). Outbreaks of such diseases are usually related to infection by common causative agents, mainly rotavirus, Salmonella enterica, and diarrheagenic Escherichia coli (Hodges and Gill, 2010; Kolenda et al., ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Microorganisms are involved in many life activities, and affect their surrounding environment and other organisms. Microorganisms play important roles in human heath, crop growth, livestock farming, environmental management, industrial chemical production and food production. In the 19th century, people first observed microbes using microscopes and began to study them. However, the development of high-throughput sequencing technology has led to generation of large amounts of microbial related data. As a result, machine-learning methods are now being applied to microbiological research. Here, we discuss the curr...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, severe lethal ileitis induced by oral T. gondii infection is attenuated by blockade of ST2 signaling and may be mediated in part by endogenous IL-22. Introduction Toxoplasma gondii is an opportunistic parasite with a worldwide distribution triggering an innate immune response. This response characterized by a rapid recruitment of neutrophils following the entry of infectious tachyzoites from the lumen into the intestinal mucosa eliciting a strong inflammatory Th1 response associated with the production of IFNγ, IL-12 and TNF-α. The parasite activates dendritic cells and macrophages to pro...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, the gut microbiota of 30 LC patients and 30 healthy controls were examined via next-generation sequencing of 16S rRNA and analyzed for diversity and biomarkers. We found that there was no decrease in significant microbial diversity (alpha diversity) in LC patients compared to controls (P observed = 0.1422), while the composition (beta diversity) differed significantly between patients and controls (phylum [stress = 0.153], class [stress = 0.16], order [stress = 0.146], family [stress = 0.153]). Controls had a higher abundance of the bacterial phylum Actinobacteria and genus Bifidobacterium, while patients wi...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Editorial: The Pathogenic Yersiniae–Advances in the Understanding of Physiology and Virulence, Second Edition Matthew S. Francis1* and Victoria Auerbuch2* 1Department of Molecular Biology, Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden2Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, United States Editorial on the Research Topic The Pathogenic Yersiniae–Advances in the Understanding of Physiology and Virulence, Second Edition Of the 18 known Yersinia species, Y. pestis, Y. pseudotuberculosis,...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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