Magnetic nano-particles retrievable biodegradable hydrogel microrobot

In this study, we fabricated the hydrogel microrobot, analyzed its characteristics (shape, size, magnetization, and drug encapsulation), verified the possibilities of targeting and disassembly of the hydrogel microrobot, and proved the retrieval of MNPs and the drug delivery from the remaining PLGA–DOX particles. Additionally, we executed the drug-releasing experiment using PLGA–DOX particles and confirmed the therapeutic effect of the hydrogel microrobot through an in vitro test using Hep3B cancer cell. We conclude that the proposed hydrogel microrobot is a new type of biocompatible microrobot with the capability of active targeting as well as toxic MNP retrieval.
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research