Eco-friendly disposal of expired anti-tuberculosis drug Isoniazid and its role in the protection of metal

This study reported results obtained from electrochemical impedance spectroscopy (EIS), polarization measurement, and weight loss, scanning electron microscopy equipped with energy dispersive x-ray analysis (SEM-EDX), atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The experimental results were excellently complemented with the results obtained from density functional theory, i.e. DFT and molecular dynamics, i.e. MD. These hydrazones inhibited corrosion by adsorbing themselves on the metal surface which was confirmed by SEM-EDX and XPS results. All the synthesized inhibitors showed appreciable efficiency (> 90%) against corrosion of mild steel in 1 M HCl medium. The activation energy increased by the presence of inhibitors (76.1, 79.8, 77.3, and 67.0 kJ mol-1 for IICH, ICCH, IBCH, and IMCH respectively) compared to that in 1 M HCl solution only (32.8 kJ mol-1). All these compounds were found to act as a mixed type of inhibitor as confirmed by shifting range of corrosion potential (30 mV, 35 mV, 18 mV, and 36 mV for IICH, ICCH, IBCH, and IMCH respectively).Graphical abstract
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research

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In this study, we observed the existence of a putative “megaplasmid,” multiple copies of ribosomal RNA operons, and high ratio of hypothetical proteins with unknown functions in the class Ktedonobacteria. Furthermore, a total of 104 antiSMASH-predicted putative biosynthetic gene clusters (BGCs) for secondary metabolites with high novelty and diversity were identified in nine Ktedonobacteria genomes. Our investigation of domain composition and organization of the non-ribosomal peptide synthetase and polyketide synthase BGCs further supports the concept that class Ktedonobacteria may produce compounds structurall...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Methanogens are important players in the carbon cycle of hypersaline habitats. However, not much is known about the characteristics of methanogens from the deep-sea brine habitats of the Red Sea and no cultures existed. In this study, we describe a novel isolate (strain RSK) from the BSI of Kebrit Deep of the Red Sea representing a novel species within the genus Methanohalophilus. In order to understand why species of the genus Methanohalophilus are successful in chemically diverse hypersaline environments, we analyzed and compared the genomic inventory among five Methanohalophilus species to elucidate genomica...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Yong Yang1,2†, Xue Bai1†, Chengyao Li1†, Mingwei Tong3, Peihao Zhang2, Wei Cai4, Xiaolei Liu1* and Mingyuan Liu1,5* 1Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Institute of Zoonosis, Jilin University, Changchun, China 2Wu Xi Medical School, Jiangnan University, Wuxi, China 3School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China 4Affiliated Hospital of Jiangnan University, The Fourth People's Hospital of Wuxi City, Wuxi, China 5Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Di...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
This study was supported by the Swiss National Science Foundation No. 31-124861 to GS. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2019.00414/full#supplementary-material References Chava, K. R., Tauseef, M., Sharma, T., and Mehta, D. (2012). Cyclic AMP response element-binding protein prevents endothelial permeability...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 23 April 2019Source: Journal of Molecular StructureAuthor(s): Grace Busayo Peleyeju, Talla Emmanuel, Charlotte Mungho Tata, Marthe Carine Djuidje Fotsing, Nicolette Niemann, Lydia Rhyman, Charmaine Arderne, Derek Tantoh Ndinteh, Ponnadurai RamasamiAbstractScandenone (warangalone) is a flavonoid found in Erythrina species and other plant genera. It has been connected with physiological processes in insects, human cells and bacteria. In this article, an overview of the biological importance of this compound is provided. A detailed analysis of its crystal structure and antibacterial properti...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Abstract Despite the advancements made in medicine and treatment of tuberculosis over the last century, it remains a significant healthcare challenge. It remains the leading cause of death from a single infectious agent and the ninth leading cause of death worldwide. A 23-year-old male with a history of tuberculosis treated in Nepal seven years prior, presented to the emergency department with one week of hemoptysis, fever, chills, night sweats and weight loss. A CT scan of the chest showed multiple cavitary lesions at the superior segment of the left lower lobe. He had persistent massive hemoptysis and required b...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Med Case Rep Source Type: research
Conclusions Decrease in cholesterol efflux, increase in uptake, and excess esterification of cholesterol compounded by the action of lipid peroxidation products generated by inflammatory processes contribute to foam cell formation in atherosclerosis. Since these are critical events in the pathogenesis of atherosclerosis, they have been extensively studied. On the contrary, although a role for host lipid metabolism in mycobacterial pathogenesis has been established, research in the different components that contribute to the alteration in host lipid metabolism and cholesterol homeostasis is still in the nascent stages. The...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
ConclusionThe diagnosis of TBP had been complicated by the presence of CP in the reported case. The underlying CP not only preclude the diagnosis of TBP, but also produced symptoms that mimicked a condition requiring surgery.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We reported a case of 10-year-old boy with ulcers in the cervical and axillary region. The lesion began as papules, which gradually developed into nodules and pustules. Chronic cough was also found, however chest x ray was normal and sputum direct smear for acid fast bacil was negative. Histopathologic finding of tissue biopsy revealed epidermal necrosis in the central part surrounded by granulomatous tissue forming an abscess and histiocyte infiltrates, confirming the diagnosis of scrofuloderma. CT Scan of neck showed multiple enlarged lymph nodes, and FNAB result was suggestive for tuberculous lymphadenitis. Patient was ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Publication date: Available online 17 April 2019Source: Respiratory Medicine Case ReportsAuthor(s): A. Haralsingh, R. RawlinsAbstractTuberculosis (TB) is a significant public health problem in many developing countries. In many cases, tuberculosis may present a significant diagnostic challenge. A 32-year-old male Chinese immigrant presented to our institution with a fever and non-productive cough. He was found to have a right pleural effusion, for which a chest drain was inserted. His tuberculin skin test was unreactive (0mm) although he was not immunocompromised (HIV negative). All cultures were negative, and 3 sputum sam...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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