Biogen pulls the plug on amyloid-targeting Alzheimer ’s drug

Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research

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Conclusions: This cutoff value can be applied clinically to evaluate brain atrophy in HD. Our method is advantageous because it is simple and can be implemented easily in daily clinical practice.Eur Neurol 2019;81:13 –18
Source: European Neurology - Category: Neurology Source Type: research
Longitudinal plasma neurofilament light (NfL) levels are associated with neurodegeneration in Alzheimer disease, researchers report.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Age and HIV-related neurodegeneration; to review basic and clinical research on commonalities and differences in molecular and cellular mechanisms underpinning and neurodegenerative diseases, particularly Alzheimer's disease, and Alzheimer's-related dementias, and neurological disorders associated with HIV infection and AIDS.Air date: 5/2/2019 8:30:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Age and HIV-related neurodegeneration: to review basic and clinical research on commonalities and differences in molecular and cellular mechanisms underpinning neurodegenerative diseases, particularly Alzheimer's disease, and Alzheimer's-related dementias, and neurological disorders associated with HIV infection and AIDS.Air date: 5/1/2019 8:30:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Publication date: Available online 24 April 2019Source: Journal of Psychiatric ResearchAuthor(s): Elise Gondard, Maria Luisa Soto-Montenegro, Amanda Cassol, Andres M. Lozano, Clement HamaniAbstractAlzheimer's disease (AD) is a progressive and debilitating degenerative disorder for which there are currently no effective therapeutic options. Non-invasive neuromodulation, including transcranial direct current stimulation (tDCS), has been investigated for the treatment of cognitive symptoms in AD. Results from clinical and preclinical studies, however, have been somewhat controversial. We investigate whether tDCS delivered to ...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 23 April 2019Source: Neurobiology of StressAuthor(s): Hongxin Dong, John G. Csernansky
Source: Neurobiology of Stress - Category: Neuroscience Source Type: research
(Bentham Science Publishers) The latest volume of Frontiers in Clinical Drug Research -- Alzheimer Disorders, published by Bentham Science Publishers covers interesting developments in the therapy of Alzheimer's disease.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
This study was carried out in accordance with the recommendations of the National Animal Care and Use Committee of the University of Buenos Aires (CICUAL). The protocol was approved by the CICUAL. Mice were kept under a 12-h light/dark cycle, with controlled temperature (23 ± 2°C) and humidity (40–60%) and had ad libitum access to food and water. To produce hTDP-43 transgenic lines, as described previously (Igaz et al., 2011), pronucleus of fertilized eggs from C57BL/6J × C3HeJ F1 matings were injected with a vector containing hTDP-43-WT cDNA. Monogenic tetO-TDP-WT12 mice wer...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study employed a double-blind, randomized, crossover design, in which 24 healthy right-handed participants conducted MEG recordings during a 3-back task after administration of 2 mA tDCS or sham stimulation as a placebo. Our results showed that the effect of tDCS did not appear in the behavioral indices—WM accuracy (d′) or reaction time (RT). From the results of the time-frequency analysis, significant event-related synchronization (ERS) in the high-gamma band (82–84 Hz) of the left DLPFC was found under the tDCS condition; however, ERS was not correlated with WM capacity. Furthermore, we calculated ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
In conclusion, we unraveled the secretome of G. adiacens, an oral bacterium well-documented in infective endocarditis, but also recently shown to be involved in oral infections. Importantly, the secretome of G. adiacens comprised of a large number of putative virulence factors. Of particular importance is the finding that the G. adiacens secretome comprised of a number of “moonlighting” proteins, which in other species are shown to enhance bacterial colonization and virulence through their multifunctional roles (Pavkova et al., 2017; Graf et al., 2019). Thus, our results provide a basis for investigating the ro...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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