Knee replacement incidence and social deprivation: results from a French ecological study

Publication date: Available online 22 March 2019Source: Joint Bone SpineAuthor(s): Murielle Michel, Joséphine Bryère, Milka Maravic, Christian MarcelliAbstractObjectives:Temporal and geographic variations in knee osteoarthritis (OA) incidence occur worldwide. Regional variations also exist for socioeconomic status. We analyzed the association between socioeconomic deprivation (SED) and knee replacement (KR) incidence and assessed the proportion of KR associated with affluence.Methods:Patients aged 15 years and over hospitalized for KR in 2013 were included. We linked each patient to a municipality of residence. Municipalities were matched to the 2011 European Deprivation Index score for SED analysis. Poisson regression was performed to examine the association between KR incidence and EDI adjusted for age and sex. The Population Attributable Fraction (PAF) was measured to calculate the proportion of excess of KR associated with social affluence.Results:We included 77 597 KR. KR incidence decreased with increasing SED index. The EDI was significantly associated with KR incidence (p 
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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ConclusionBMHR prostheses are metal-on-metal implants that resulted from the development of the standard resurfacing prostheses used to treat hip osteoarthritis in young patients with the goal of preserving as much bone stock as possible.In this paper we will describe a rare complication in this type of prosthesis and how it was surgically treated after reviewing the available literature.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionBimeniscal replacement by an allograft and/or substitute provides good short-term functional and anatomical outcomes. Nevertheless, this procedure is warranted only in highly selected patients.Level of evidenceIV, retrospective study.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Fengfeng Nie, Fei Ding, Bo Chen, Shouguo Huang, Qingbai Liu, Changming XuAbstractAimsDendritic cells (DCs) and Toll-like receptor (TLR) participate in mediating inflammation process. However, the functional role of TLR expressed on DCs in osteoarthritis (OA) development has not been defined yet. The purpose of this study was to investigate the role and mechanism of TLR and DCs in the progression of experimental osteoarthritis (OA).Materials and methodsExperimental OA model was induced by iodoacetate injection. Expressions of toll-like recepto...
Source: Life Sciences - Category: Biology Source Type: research
The OsteoArthritis and Therapy for Sleep (OATS) study is a population-based randomized controlled trial of cognitive behavioral therapy for insomnia (CBTI) with four innovative methodological aims. These are to: (1) Enroll representative participants across Washington state, including those from medically underserved communities; (2) Enroll persons with persistent insomnia and chronic osteoarthritis (OA) pain; (3) Test a scalable CBT-I intervention; and (4) Evaluate patient-reported outcomes (insomnia, pain severity, fatigue, depression) and cost-effectiveness over one year.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Source Type: research
ConclusionsThese data suggest that interactions between the major constituents of this supplement combination are unlikely and therefore could be investigated to manage patients with osteoarthritis without significant concerns for possible pharmacokinetic interactions.
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research
Publication date: Available online 11 October 2019Source: Arthroscopy TechniquesAuthor(s): Joseph N. Liu, Troy G. Shields, Anirudh K. Gowd, Nirav H. AminAbstractBone marrow lesions (BMLs) in the knee represent focal edema caused by subchondral bone attrition and microfractures to the trabecular bone. These lesions are poor prognostic indicators for several orthopaedic procedures but also have been associated with the progression of osteoarthritis. Current research is aimed at treating BMLs with the intent to improve the overall structural integrity of the subchondral bone and delay the need for arthroplasty. The injection ...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
ConclusionS. tuberculata reduced the damage due to oxidative stress and pain caused by knee osteoarthritis in rats. In addition, the infusion presented no toxicity. Our results suggest that S. tuberculata seems to have a therapeutic potential in the osteoarthritis treatment.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Condition:   Knee Osteoarthritis Intervention:   Behavioral: standardized exercise therapy for knee OA patients Sponsor:   Aalborg University Recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Osteoarthritis, Knee Intervention:   Biological: XT-150 Sponsor:   Xalud Therapeutics, Inc. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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