Cangrelor or Clopidogrel in Patients with Type 2 Diabetes Mellitus Undergoing Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Controlled Trials

ConclusionsIn these patients with T2DM, cangrelor was comparable to clopidogrel in terms of efficacy at 48  h following PCI. However, it was associated with significantly higher mild GUSTO bleeding and major and minor ACUITY bleeding, therefore requiring further workups on its safety side. This hypothesis should be explored further and confirmed in other forthcoming trials based strictly on patients wit h T2DM.
Source: Diabetes Therapy - Category: Endocrinology Source Type: research

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Publication date: Available online 12 October 2019Source: The Lancet Respiratory MedicineAuthor(s): Stefano Barco, Seyed Hamidreza Mahmoudpour, Luca Valerio, Frederikus A Klok, Thomas Münzel, Saskia Middeldorp, Walter Ageno, Alexander T Cohen, Beverley J Hunt, Stavros V KonstantinidesSummaryBackgroundEuropean estimates of the burden imposed by pulmonary embolism are not available to this date. We aimed to assess pulmonary embolism-related mortality and time trends in the WHO European Region.MethodsWe analysed vital registration data from the WHO Mortality Database (2000–15) covering subregions of the WHO Europea...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
ConclusionsExtra-pelvic endometriosis, traditionally thought to be rare, have been reported in a considerable number of cases. Heightened awareness and clinical suspicion of the disease, and multi-disciplinary approach is recommended to achieve prompt diagnosis and optimize patient outcomes. At this time, there are no comparative studies to provide recommendations regarding optimal diagnostic methods, treatment options and outcomes for endometriosis involving extra-pelvic sites.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
The objective of this study was to evaluate the influence of gross tumor morphology on clinicopathological profile of CRCs in Kashmiri population.MethodsThis 5-year study is a prospective (2 yrs) and retrospective (3 yrs) study conducted from 2011 to 2016 in the Colorectal Surgery Division at Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Kashmir, India. Parameters studied were age, sex, site of lesion, clinical presentations, gross tumor morphology, and histopathology of the lesion.ResultsA total of 930 patients with CRC were included. Infiltrative variety was the most common morphology in patients aged 1...
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
ConclusionNeedle flexor tenotomies are a relatively safe and effective treatment compared to tenotomies done by scalpel, both as treatment for ulcers and to prevent formation of new ulcers associated with hammer, mallet and claw toe deformities. As a side note, transfer complications are avoidable if all toes on one or both feet are tenotomized in one procedure.
Source: Journal of Clinical and Translational Endocrinology - Category: Endocrinology Source Type: research
ConclusionOur study showed a significant association between alterations in intestinal microbial composition and T1D; however, in some articles, it is not clear which one happens first. Investigation of altered gut microbiota can help in the early detection of T1D before seropositivity. Targeted microbiome modulation can be a novel potential therapeutic strategy.
Source: Gut Pathogens - Category: Microbiology Source Type: research
This study aimed to compare short- and long-term results for patients undergoing either aortic valve-sparing reimplantation (David) procedure (AVr-D) or biological aortic root replacement (Bentall) procedure (ARr-B-bio) for aortic root pathology.MethodsWe compared outcomes for patients who underwent AVr-D (n = 261) or ARr-B-bio (n = 150) between 2000 and 2015 at our institution. The mean age of patients was 55 ± 13 years and 21.7% (n = 89) were female. ARr-B-bio patients were significantly older than AVr-D patients (58 ± 10 vs 53&thins...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Bhullar SK, Shah AK, Dhalla NS Abstract Effective therapy of hypertension represents a key strategy for reducing the burden of cardiovascular disease and its associated mortality. The significance of voltage dependent L-type Ca²⁺ channels to Ca²⁺ influx, and of their regulatory mechanisms in the development of heart disease, is well established. A wide variety of L-type Ca²⁺ channel inhibitors and Ca²⁺ antagonists have been found to be beneficial not only in the treatment of hypertension, but also in myocardial infarction and heart failure. Over the past two decades, another cla...
Source: Reviews in Cardiovascular Medicine - Category: Cardiology Tags: Rev Cardiovasc Med Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Liquids, Volume 296Author(s): Małgorzata Biedulska, Agnieszka Chylewska, Dawid NidzworskiAbstractThe detailed studies concerning the binding mode of bioactive ligands: pyrazine-2-carboxamide (PZA), pyrazine-2-thiocarboxamide (PTCA) and pyrazine-2-amidoxime (PAOX) have been performed by using three independent techniques: UV–Vis spectroscopy, potentiometry and conductometry. The composition and stability constants of new series Ir(III) complexes with antituberculosis drug and its structural analogues have been determined in aqueous and nonaqueous solution...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
These diets can reduce the risk of coronary heart disease and the risk of diabetes as well as keeping you in shape. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Heart Disease Source Type: blogs
Conclusion: In elective PCI, low-dose UFH with sequential enoxaparin has similar effects and safety to the UFH-only method. PMID: 29578118 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
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