Paediatric inflammatory bowel disease: review with a focus on practice in low- to middle-income countries.
Paediatric inflammatory bowel disease: review with a focus on practice in low- to middle-income countries. Paediatr Int Child Health. 2019 Feb;39(1):48-58 Authors: Dalzell AM, Ba'Ath ME Abstract Inflammatory bowel disease (IBD) should be considered in any child with a persistently altered bowel habit. Growth failure may be a consequence and there may also be extra-intestinal manifestations. Oesophago-gastroduodenoscopy and colonoscopy and conventional histopathology are the diagnostic tools of choice in IBD. The identification and management of children with IBD in resource-poor settings is difficult and there are few data on its prevalence in low- and middle-income countries. The main challenges are a lack of resources and infrastructure including trained personnel in settings where there are other priorities for maintaining the health and wellbeing of children. The identification and management of children with inflammatory bowel conditions often depends on the enthusiasm, skill and commitment of a few dedicated individuals. Abbreviations: ADA: Adalimumab; CD: Crohn disease; ECCO: European Crohn's and Colitis Organisation; EEN: exclusive enteral nutrition; ESPGHAN: European Society for Paediatric Gastroenterology Hepatology and Nutrition; FMT: faecal microbiota transplantation; GDP: gross domestic product; HIC: high-income countries; IBD: inflammatory bowel disease; IBDU: inflammatory bowel disease unclassified; IC: ileocolonoscopy; IFX: infliximab; IPA...
This study analyzed the long-term incidence of malignancy with vedolizumab, a gut-selective antibody approved to treat moderate-to-severe Crohn's disease and ulcerative colitis in adults.Alimentary Pharmacology &Therapeutics
CONCLUSIONS: Testing for S100B and calprotectin could be a useful screening tool to better predict IBD activity. PMID: 31957846 [PubMed - in process]
Conclusion and Relevance: In our meta-analysis, obesity was associated with the inferior response of anti-TNF treatments in UC patients. Clinicians should be aware that obese UC patients may require higher doses in anti-TNF treatment. PMID: 31955605 [PubMed - as supplied by publisher]
This review explores the role of gut fungi in patients with Crohn's disease and ulcerative colitis. Might modulation of the fungal microbiota present a therapeutic opportunity for IBD?Alimentary Pharmacology &Therapeutics
The objective is to examine whether children with inflammatory bowel disease (IBD: Crohn ’s disease and ulcerative colitis), coeliac disease, asthma and juvenile idiopathic arthritis (JIA) have an altered body composition as compared to healthy children.
Conclusions: Postoperative VTE risk varies widely by the operation performed, and a diagnostic indication of CD or UC does not play a role. Extended duration VTE prophylaxis should be considered in all patients undergoing high-risk operations, regardless of their underlying diagnosis.
Despite advances in therapeutic options, a sizeable proportion of patients with inflammatory bowel disease require hospitalization or surgery during their lifetime. While current treatment guidelines for the management of ulcerative colitis and Crohn ’s disease cover the spectrum of disease severity and behavior, management of acute complications of inflammatory bowel disease can present unique challenges that are not always addressed in these guidelines. In this review, the authors provide a comprehensive summary of the existing literature fo cused on management of patients hospitalized with complications of inflammatory bowel disease.
In this study, we studied the effects of vehicle and host intestinal microflora on carrageenan inflammatory properties in C57BL/6 J mice. We found that in high-fat diet model, native carrageenan in drinking water increased the disease activity index (DAI), myeloperoxidase (MPO) activity and the mRNA expression of TLR4 in colon, whereas carrageenan-supplemented diet has no visible effects. However, no signs of colitis were observed under low-fat diet regardless of the mode of vehicle used. Moreover, we discovered that carrageenan-induced colitis in high-fat diet model was robustly correlated with changes in the compositio...
ConclusionProstasin has an anti-inflammatory effect via downregulation of TLR4 expression in colonic epithelial cells. Reduced prostasin expression in IBD mucosa is linked to the deterioration of local anti-inflammatory activity and may contribute to the persistence of mucosal inflammation.
ash;ivik ML Abstract The aim was to analyse the importance of childbearing for inflammatory bowel disease risks. Using data from the Norwegian Population Register and the Norwegian Patient Register, discrete-time hazard models for diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) were estimated for men and women of age 18-81 in 2011-2016. Year and various socio-demographic factors were controlled for. The data included 4304 CD and 8866 UC cases. Women whose youngest child was 0-4 years old had lower CD risk the following year than the childless (OR 0.73, CI: 0.62, 0.86). There was no such reduction in C...