Cancer stem cells in radiation response: current views and future perspectives in radiation oncology.

CONCLUSION: Evidence from both, experimental and clinical studies demonstrates that the probability of achieving local tumor control by radiation therapy depends on the complete eradication of CSC populations. The number, properties and molecular signature of CSCs are highly predictive for clinical outcome of radiotherapy, whereas targeted therapies against CSCs combined with conventional treatment are expected to provide an improved clinical response and prevent tumor relapse. In this review, we discuss the modern methods to study CSCs in radiation biology, the role of CSCs in personalized cancer therapy as well as future directions for CSC research in translational radiooncology. PMID: 30897014 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research

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Detection of N6‑methyladenosine modification residues (Review). Int J Mol Med. 2019 Jun;43(6):2267-2278 Authors: Zhu W, Wang JZ, Xu Z, Cao M, Hu Q, Pan C, Guo M, Wei JF, Yang H Abstract Among a number of mRNA modifications, N6‑methyladenosine (m6A) modification is the most common type in eukaryotes and nuclear‑replicating viruses. m6A has a significant role in numerous cancer types, including leukemia, brain tumors, liver cancer, breast cancer and lung cancer. Although m6A methyltransferases are essential during RNA modifications, the biological functions of m6A and the underlying mechanisms rem...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
In conclusion, we believe that the data presented in this research add new relevant information for a better definition of the pathological states associated with HTLV-1 infection, particularly in relation to the distinct subcellular expression of HBZ in the different pathological contests and related pathologies. Whether HBZ cytoplasmic and nuclear localization in the natural history of HTLV-1 infection represents a marker of infection or is part of the mechanism governing the evolution toward HAM/TSP or ATL is the challenge for future investigation. Author Contributions GF, MB, and RA conceived the work. GF, MB, and AT...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Inspired by the general network co-neighbors, this paper proposed the definition of the co-neighbors of the bipartite network based on the hypothesis that that functionally similar miRNAs are related to phenotypically similar diseases. Eight local structural similarity indexes which are co-neighbor, Salton, Jaccard, Sørensen, HPI, HDI, LHN1, and PA were used to measure the association probabilities between nodes. Several types calculation methods of computational miRNA-disease prediction score were introduced, namely, the bipartite network co-neighbor link prediction score using only known association in...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conditions:   Myelodysplastic Syndromes;   Acute Myeloid Leukemia Intervention:   Drug: PRGN-3006 T Cells Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   Precigen, Inc Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Lund University) The most common form of childhood cancer is acute lymphoblastic leukaemia (ALL). Researchers at Lund University in Sweden, in cooperation with Karolinska Institutet, SciLifeLab and the University of Cambridge, have now carried out the most extensive analysis to date of ALL at the protein level, by studying the activity in over 8 000 genes and proteins. The results show aberrant folding in the DNA string, which in turn affects the genes' activity. The study was recently published in Nature Communications.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(Beth Israel Deaconess Medical Center) Researchers tested to see if arsenic trioxide (ATO) was effective in combination with all-trans retinoic acid (ATRA) in in both the mouse model of acute myeloid leukemia (AML) and in human AML cells in the lab, and determined that the combination proved 'powerfully and exquisitely effective' against a subset of AML. The combo could serve as the foothold researchers need to overcome resistance to therapy -- a common challenge in treating AML.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(University of Edinburgh) New findings about an aggressive form of leukemia could aid the development of novel drugs to treat the condition.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Therefore, subtype classification is important and indispensable in ALL diagnosis. In ...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
In this study, we firstly tested the effects of QJSB on leucopenia using mice induced by cyclophosphamide. Our results suggested that QJSB significantly raised the number of peripheral white blood cells, platelets and nucleated bone marrow cells. Additionally, it markedly enhanced the cell viability and promoted the colony formation of bone marrow mononuclear cells. Furthermore, it reversed the serum cytokines IL-6 and G-CSF disorders. Then, using transcriptomics datasets and metabonomic datasets, we integrated transcriptomics-based network pharmacology and metabolomics technologies to investigate the mechanism of action o...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions In this review, we collected all the information concerning the OMICs studies performed on HS patients aimed at unraveling the mechanisms at the basis of the disease or associated to clinical severity and/or the successful response to pharmacological treatment (including biological drugs). The general picture of the OMICs contribution in the context of HS is not so clear and/or rich of clinical useful information, since most of the studies focused only on one aspect (genome, transcriptome, or proteome) of the disease, enrolling small numbers of patients (this is quite limiting for the genetic studies) from di...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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