The absence of NIPA2 enhances neural excitability through BK (big potassium) channels.

CONCLUSION: The results indicate that the absence of NIPA2 enhances neural excitability through BK channels. Zonisamide is probably a potential treatment for NIPA2 mutation-induced epilepsy, which may provide a basis for the development of new treatment strategies for epilepsy. PMID: 30895737 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30895737?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - March 19, 2019 Category: Neuroscience Authors: Liu NN, Xie H, Xiang-Wei WS, Gao K, Wang TS, Jiang YW Tags: CNS Neurosci Ther Source Type: research