Endometriosis Awareness Month

March is Endometriosis Awareness Month.  Endometriosis is a painful condition where endometrial tissue grows outside the uterus. It is estimated that up to 10% of women have endometriosis (Ozkan 2008).   Endometriosis can cause infertility and for women with subfertility the prevalence rate ranges from 25% to 40% (Ozkan 2008). Endometriosis frequently presents with the symptom of pain (Barlow 1993) including dysmenorrhoea (painful periods), dyspareunia (pain during sexual intercourse), and pelvic or abdominal pain.  We invited Edgardo Somigliana, MD-PhD (Dept Clinical Sciences and Community Health, Universit à degli Studi di Milano, Milan, Italy) to share his clinical view on endometriosis:“Endometriosis is an enigmatic but curable disease. Significant improvements have been reached over the last two decades and most women can now be effectively cured. Indeed, when properly combined, surgery, hormonal medical therapy and assisted reproductive techniques can overcome endometriosis-re lated symptoms in the vast majority of cases. These results have not be obtained with revolutionary new therapies but, conversely, through a wiser use of the available tools (Vercellini 2015). Several challenges remain. Of utmost relevance is still disentangling the origin and pathogenesis of the disease. This unsolved issue is crucial and only progresses in this area could open new avenues or research that can ultimately lead to significant steps forwards, including pr...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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Endometriosis is known to have a remarkably negative effect on the Quality of Life (QOL) of the women. Surgery is considered when medical therapy is unsuccessful or in the setting of infertility. A high recurrence rate is reported in advanced stages of endometriosis. Thus, Complete excision and prevention of recurrence is particularly important. Following hysterectomy, pelvic pain and vaginal bleeding are a rare but real occurrence. We evaluated the recurrence of pain and bleeding in patients following hysterectomy and infertility sparing procedures.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Open Communications 27:  Endometriosis (4:10 PM – 5:10 PM) 4:52 PM Source Type: research
Conclusion Dyspareunia and acyclic pain were independent factors of correlation with high scores in the EHP-30 questionnaire, reflecting a worse quality of life.Resumo Objetivo Avaliar a exist ência de associação entre os achados ultrassonográficos e os fatores epidemiológicos e clínicos com os resultados obtidos no questionário EHP-30 em mulheres com diagnóstico de endometriose ovariana. Métodos Realizou-se um estudo observacional transversal entre julho de 2012 emaio de 2015, no qual as pacientes com dor pélvica crônica com imagem sugestiva de end...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Endometriosis is a common cause of chronic pelvic pain, dysmenorrhea and infertility. Although 6 –10% of women of child bearing age are affected by the disease, and even more in the group of patients with fertility problems, diagnosis is often delayed and treatment can be challenging. Depending on the complaints, extent of disease and the goals of treatment (fertility treatment, pain reducti on, …), both medical and surgical options are available for the management of this pathology and often a  multidisciplinary approach will be necessary. Although diagnostic laparoscopy with histologic confirmation...
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research
ConclusionGreater awareness of HWWS will lead to earlier detection and is the key to alleviating patient suffering and avoiding potentially severe complications.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Modifiable risk factors such as diet may be important in both the etiology and progression of endometriosis as well as the prevalence of pain symptoms and infertility associated with this condition. In adults, higher intake of dairy has been associated with lower risk of endometriosis diagnosis. There is currently no literature on whether dairy intake during adolescence - a potentially critical window of exposure - influences endometriosis risk.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Original Research: Gynecology Source Type: research
ConclusionsOur data confirm that endometriosis is a disease which probably progresses from adolescence until the adult period, when symptoms (pain or infertility) become debilitating and require surgery. Our data suggest that policies relating to the prevention and early diagnosis of endometriosis should focus on women under the age of 25 years.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionTraditionally only pathologies of the uterus and ovaries are assessed during a routine pelvic ultrasound. Here we demonstrate that the routine ultrasound examination can easily be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments to evaluate structural mobility and to look for deep infiltrating endometriotic nodules, so women suffering from deep infiltrating endometriosis can benefit from a pre-operative diagnosis and subsequently a single, well-planned procedure in the hands of a well-prepared team.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
The objective of this work was to determine whether CD55 protein is expressed in ectopic endometrium, whether PGE2 is a regulator of CD55 expression, and whether CD55 is necessary and sufficient for endometriosis pathogenesis via a non-canonical pathway.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
Reproductive surgery for proximal and distal tubal occlusion, as well as for reversal of tubal ligation, may be an alternative or an adjunct to IVF. Surgery for adenomyosis and endometriosis, including endometriomas, may be considered for the treatment of infertility and/or pelvic pain but carries the risks of surgical complications and diminished ovarian reserve. A greater understanding of the pathogenesis of postoperative peritoneal adhesion formation is needed to develop more effective preventive measures to optimize the clinical results of surgery.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Views and reviews Source Type: research
Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6% to 10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be used for patients wishing to become pregnant. Despite the high morbidity, the pathogenesis of endometriosis has not been well elucidated. Several inflammatory cytokines are reported to participate in the onset of endometriosis. Here, we examined the role of interleukin (IL)-1/IL-33 signaling in the develop...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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