Contribution of STAT3 and RAD23B in primary S ézary cells to histone deacetylase inhibitor FK228 resistance

This study investigates RAD23B and STAT3 gene perturbations in a large cohort of primary Sézary cells and the effect of FK228 treatment on tyrosine phosphorylation of STAT3 (pYSTAT3) and RAD23B expression. We report RAD23B copy number variation in 10% (12/119; p ≤ 0.01) of S S patients, associated with reduced mRNA expression (p = 0.04).

Source: Journal of Investigative Dermatology - March 21, 2019 Category: Dermatology Authors: Rosie M. Butler, Robert C. McKenzie, Christine L. Jones, Charlotte E. Flanagan, Wesley J. Woollard, Maria Demontis, Silvia Ferreira, Isabella Tosi, Susan John, Sean J. Whittaker, Tracey J. Mitchell Tags: Original Article Source Type: research