Encapsulated melatonin in polycaprolactone (PCL) microparticles as a promising graft material

Publication date: July 2019Source: Materials Science and Engineering: C, Volume 100Author(s): Esra Bihter Gurler, Necdet Mekki Ergul, Burak Ozbek, Nazmi Ekren, Faik Nuzhet Oktar, Merve Erginer Haskoylu, Ebru Toksoy Oner, Mehmet Sayıp Eroglu, Dilek Ozbeyli, Veysel Korkut, Ahmet Furkan Temiz, Nil Kocanalı, Rosa Juvan Gungordu, Duhan Berkan Kılıckan, Oguzhan GunduzAbstractElectrospraying assures many advantages with taking less time and costing less relatively to the other conventional particle production methods. In this research, we investigated the encapsulation of melatonin (MEL) hormone in polycaprolactone (PCL) microparticles by using electrospraying method. Morphology analysis of the produced particles completed with Scanning Electron Microscopy (SEM). SEM images demonstrated that micro-particles of 3 wt% PCL solution has the most suitable particle diameter size (2.3 ± 0.64 μm) for melatonin encapsulation. According to the characterization of the particles, electrospraying parameters like optimal collecting distance, the flow rate of the solution and voltage of the system detected as 8 cm, 0.5 ml/h, and 10 kV respectively. For determining the chemical bonds of scaffold Fourier-Transform Infrared Spectroscopy (FTIR) were used and FTIR results showed that melatonin successfully loaded into PCL micro-particles. Drug release kinetics of the melatonin loaded particles indicated that melatonin released with a burst at the beginning and release behavior becam...

Source: Materials Science and Engineering: C - March 23, 2019 Category: Materials Science Source Type: research