Molecules, Vol. 24, Pages 1151: The Pros and Cons of Cystic Fibrosis (CF) Patient Use of Herbal Supplements Containing Pulmonaria officinalis L. Extract: the Evidence from an In Vitro Study on Staphylococcus aureus CF Clinical Isolates
Molecules, Vol. 24, Pages 1151: The Pros and Cons of Cystic Fibrosis (CF) Patient Use of Herbal Supplements Containing Pulmonaria officinalis L. Extract: the Evidence from an In Vitro Study on Staphylococcus aureus CF Clinical Isolates
Molecules doi: 10.3390/molecules24061151
Authors:
Beata Sadowska
Urszula Wójcik
Justyna Krzyżanowska-Kowalczyk
Mariusz Kowalczyk
Anna Stochmal
Joanna Rywaniak
Julia Burzyńska
Barbara Różalska
The justification for the use of herbal supplements with Pulmonaria officinalis L. extract (POE) in the case of staphylococcal lung colonization/infections characteristic for cystic fibrosis (CF), was examined in vitro. The impact of POE phenolic-rich fraction on the virulence attributes of CF-associated Staphylococcus aureus (S. aureus) clinical strains has been assessed, including pathogen adhesion, biofilm formation on native and protein-conditioned surfaces (mucin, elastin), mature biofilm eradication, staphylococcal protein A expression, α-toxin release, and S. a. adhesion to A549 cells. Cytotoxicity of the extract to lung epithelial cells was also investigated. It was found that POE has bacteriostatic effects at MIC 1–2 mg/mL, recognized as of limited efficacy, but at MIC/subMICs it targeted virulence not viability. It usually decreased S. aureus adhesion and less frequently inhibited biofilm formation on native and protein-conditioned surfaces. Observed effect seems to be related to significant ...
Source: Molecules - Category: Chemistry Authors: Beata Sadowska Urszula W ójcik Justyna Krzy żanowska-Kowalczyk Mariusz Kowalczyk Anna Stochmal Joanna Rywaniak Julia Burzy ńska Barbara R óżalska Tags: Article Source Type: research
More News: Chemistry | Complementary Medicine | Cystic Fibrosis | Herbs | Staphylococcus Aureus | Study