Microfluidic one-step preparation of alginate microspheres encapsulated with in situ-formed bismuth sulfide nanoparticles and their photothermal effect

Publication date: Available online 22 March 2019Source: European Polymer JournalAuthor(s): Qian Zou, Fangli Hou, Hong Wang, Yonggui Liao, Qin Wang, Yajiang YangAbstractMultifunctional alginate microspheres encapsulated with in situ-formed bismuth sulfide nanoparticles (denoted as Bi2S3@BCA) were developed in this work. In comparison with conventional hybrid polymer microspheres usually involved in complicate preparation process, Bi2S3@BCA microspheres can be easily one-step prepared using a droplet-based microfluidic technique with alginate as a soft template and microspheric matrix. As-prepared Bi2S3@BCA microspheres has unique nano-in-micro structure. The obtained wet microspheres show good uniform size with approximately 150 μm in diameter. Scanning electron microscopy images show that Bi2S3 nanoparticles with a size of 300 nm were homogeneously distributed in the microspheres. In addition, Bi2S3@BCA microspheres exhibit strong absorption of near-infrared (NIR) light and excellent photothermal effect in vitro. Furthermore, anti-cancer drug (doxorubicin)-loaded Bi2S3@BCA microspheres show sustained drug release behavior and enhanced release rate under NIR laser irradiation. The in vitro cytotoxicity experiments confirm that chemotherapy combined with NIR-induced hyperthermia can act synergistic effect to kill more tumor cells. Therefore, the as-prepared drug-loaded Bi2S3@BCA microspheres may potentially be used as a novel embolic material for tumor therapy due to their m...
Source: European Polymer Journal - Category: Chemistry Source Type: research

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In this study, we firstly tested the effects of QJSB on leucopenia using mice induced by cyclophosphamide. Our results suggested that QJSB significantly raised the number of peripheral white blood cells, platelets and nucleated bone marrow cells. Additionally, it markedly enhanced the cell viability and promoted the colony formation of bone marrow mononuclear cells. Furthermore, it reversed the serum cytokines IL-6 and G-CSF disorders. Then, using transcriptomics datasets and metabonomic datasets, we integrated transcriptomics-based network pharmacology and metabolomics technologies to investigate the mechanism of action o...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: Fat fraction on MRI corresponded to fat content on histology and therefore contributes to lesion characterization. Measurement repeatability was excellent for ADC; this parameter increased significantly post-radiotherapy even in disease categorized as stable by size criteria, and corresponded to cellularity on histology. ADC can be utilized for characterizing and assessing response in heterogeneous retroperitoneal sarcomas. Introduction Soft-tissue sarcomas are often highly heterogeneous tumors with variable components that can include cellular tumor, fat, necrosis, and cystic change. In many soft-tissue ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Laia Gorchs1*, Carlos Fernández Moro1,2, Peter Bankhead3, Katharina P. Kern1, Imrul Sadeak1, Qingda Meng1, Elena Rangelova4,5 and Helen Kaipe1,6* 1Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden 2Department of Pathology/Cytology, Karolinska University Hospital, Stockholm, Sweden 3Division of Pathology, Centre for Genomic &Experimental Medicine, Western General Hospital, Institute of Genetics &Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 4Department of CLINTEC, Karolinska Institutet, Stockholm, Sweden 5Pancreatic Surgery Unit, Center for Digesti...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we showed that KSHV-infected cells induce interferon-stimulated genes (ISGs) response but not type I interferon in uninfected bystander cells using EVs. mRNA microarray analysis showed that ISGs and IRF-activating genes were prominently activated in EVs from KSHV-infected cells (KSHV EVs)-treated human endothelial cells, which were validated by RT-qPCR and western blot analysis. We also found that this response was not associated with cell death or apoptosis by virus infection. Mechanistically, the cGAS-STING pathway was linked with these KSHV EVs-mediated ISGs expressions, and mitochondrial DNA on the surfa...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
McALLEN, Texas — Edgar carries a red folder bulging with paperwork, bills and medical records. Before his lung cancer diagnosis in September, he had about $11,000, he said, money he was saving to purchase a used truck and to pay an immigration attorney to pursue legal residency. By February, it was gone, and Edgar was relying on friends and family to cover doctor appointments, food and other basics. His treatment had been complicated by a collapsed lung. “I’m not able to work — I’m breathing with just one lung,” said the 50-year-old painter, who asked to be identified by only his first n...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized public health Source Type: news
Conclusions In the span of a very short time—less than a decade—robotic head and neck surgery has transformed the management of the head and neck cancer, and it seems clear that the future of treatment for these cancers lies in a multimodal approach in which TORS is likely to play an important role. Nevertheless, it is important to keep in mind that the current indications for TORS are limited and long-term data on the safety and oncological outcomes are needed to better understand the true role of TORS in treatment of head and neck cancer. Nonetheless, the emergence of ever more advanced robotic instruments i...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: This prospective multicenter study provides information on the current incidence and outcome of IFD in the real life setting. Practice variation between the centers may help to ultimately improve antifungal management in children at highest risk for IFDs. Introduction Available data on the incidence and outcome of invasive fungal diseases (IFD) in children treated for a hematological malignancy or undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are mostly based on single site, retrospective studies or on studies performed prior to the availability of newer compounds such as broad-sp...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Chan Feng1, Donglei Zhu1, Lv Chen1, Yonglin Lu1, Jie Liu1, Na Yoon Kim2, Shujing Liang1, Xia Zhang1, Yun Lin1, Yabin Ma3* and Chunyan Dong1* 1Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China 2Department of Chemical Engineering, Northeastern University, Boston, MA, United States 3Pharmacy Department, Shanghai East Hospital, Tongji University, Shanghai, China The off-target activation of photosensitizers is one of the most well-known obstacles to effective photodynamic therapy (PDT). The selected activation of photosensitizers in cancer cells is highly desired to overcome this problem. We...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: The prevalence of hepatic late adverse effects among studies with an adequate outcome definition varied considerably from 1% to 53%. Evidence suggests that radiotherapy involving the liver, higher BMI, chronic viral hepatitis and longer follow-up time or older age at follow-up increase the risk of hepatic late adverse effects. In addition, there may be a suggestion that busulfan, thioguanine, hepatic surgery, higher alcohol intake (>14 units per week), metabolic syndrome, use of statins, non-Hispanic white ethnicity, and older age at cancer diagnosis increase the risk of hepatic late adverse effects. High-q...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
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