Total syntheses of dehydrobotrydienal, dehydrobotrydienol and 10-oxodehydrodihydrobotrydial

Publication date: Available online 21 March 2019Source: Chinese Chemical LettersAuthor(s): Zichun Zhang, Dandan Zhao, Yingdong He, Zhen Yang, Jianxian GongAbstractIn this paper, we report the concise total syntheses of three botryane sesquiterpenoids: dehydrobotrydienal, dehydrobotrydienol, and 10-oxodehydrodihydrobotrydial. The key transformations include tandem Co-tetramethylthiourea-catalyzed Pauson–Khand and 6π-electrocyclization reactions to forge the tricyclic core structure of the botryanes, and further oxidative aromatization and oxidation to complete the total syntheses.Graphical AbstractConcise total syntheses of dehydrobotrydienal, dehydrobotrydienol, and 10-oxodehydrodihydrobotrydial were accomplished via tandem Pauson–Khand and 6π-electrocyclization reactions.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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