DNA tetrahedron-based nanogels for siRNA delivery and gene silencing.

DNA tetrahedron-based nanogels for siRNA delivery and gene silencing.
Chem Commun (Camb). 2019 Mar 21;:
Authors: Xue H, Ding F, Zhang J, Guo Y, Gao X, Feng J, Zhu X, Zhang C
Abstract
DNA tetrahedra are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery. With a compact architecture that embeds functional siRNA inside, the self-assembled nanogel can efficiently enter cells and knock down the target gene expression, making them potential noncationic vectors for functional nucleic acid delivery.
PMID: 30896698 [PubMed - as supplied by publisher]

Source: Chemical Communications - March 20, 2019 Category: Chemistry Authors: Xue H, Ding F, Zhang J, Guo Y, Gao X, Feng J, Zhu X, Zhang C Tags: Chem Commun (Camb) Source Type: research