Cost-Effectiveness Analysis of Treatment for Metastatic Renal Carcinoma in Romania.

Cost-Effectiveness Analysis of Treatment for Metastatic Renal Carcinoma in Romania. J Med Life. 2018 Oct-Dec;11(4):306-311 Authors: Liviu Preda A, Galieta Mincă D Abstract Rationale: In recent years, the cost of several treatment options for renal cancer have been supported by the Romanian healthcare system for both first- and second-line therapies. First-line alternatives through real-life efficacy and amplitude of adverse reactions may influence the efficacy and costs of patients treated with second-line treatment. Objective: Estimation of the cost-effectiveness and cost-benefit ratio for first-line treatment alternatives: Sunitinib and Pazopanib from the payer's perspective in the Romanian healthcare system. Methods and Results: We developed a Markov model to calculate the cost-effectiveness and cost-benefit ratio for 2 cohorts of patients using the results from the COMPARZ study for efficacy (progression-free survival, general survivability and quality of life) and safety and costs from national hospital databases. For an estimated population of 800 patients, Pazopanib has a quantified benefit of 7.19 years in progression-free survival, 11.71 life years gained and 8.97 years of quality-adjusted life-years compared to Sunitinib. The analysis is limited by the accuracy of the national data used and the transposition of general data on efficacy and safety at the local level. PMID: 30894887 [PubMed - in process]
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research