7T finds epilepsy abnormalities missed at lower field strengths
The ultrahigh field strength of 7-tesla MRI can identify brain abnormalities...Read more on AuntMinnie.comRelated Reading: Is 7-tesla MRI ready yet to go clinical? Can 7-tesla MRI make the transition to clinical prime time? AI, diffusion MRI can predict outcomes for epilepsy 3D-printed head phantom helps calibrate 7T MRI 7T MRI with glutamate uncovers epileptic seizure sites
Conditions: Epilepsy; SUDEP Intervention: Other: 6% Carbon dioxide/50% oxygen/balance nitrogen mixture Sponsor: University of Iowa Not yet recruiting
ConclusionThis retrospective observational study provides evidence supporting the effectiveness of PER as a first add-on therapy in patients with partial epilepsy. Importantly, the seizure-free rate was better when PER was used as a first, rather than a second or later, add-on treatment.
This article is part of the Special Issue “Prevent 21: SUDEP Summit - Time to Listen"
ConclusionsThis study found that participating in Project UPLIFT directly reduced the number of seizures experienced by participants with epilepsy. This was not mediated by the change in depression. Participation in Project UPLIFT also reduced their perceived seizure severity indirectly, through reducing their depressive symptoms. This suggests Project UPLIFT may have the potential to impact the health, healthcare costs, and well-being of people with epilepsy.
Publication date: Available online 21 October 2019Source: Epilepsy &BehaviorAuthor(s): Ramin Goudarzi, Golnaz Zamanian, Alireza Partoazar, Ahmadreza DehpourAbstractArthrocen, an avocado/soy unsaponifiable (ASU)-containing agent, is now used in the clinic and has potentially to decrease joint inflammation and pain associated with mild to severe osteoarthritis. Phytosterols are the major component of Arthrocen with documented anti-inflammatory properties, antioxidant, and analgesic effects.Here, we evaluated ASU anticonvulsant effect by its oral administration in pentylenetetrazole (PTZ)-induced seizure threshold and Max...
Contributors : Katherine A McCulloch ; Kingston Zhou ; Yishi JinSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansNeuropeptides are secreted molecules that have conserved roles modulating many processes, including mood, reproduction, and feeding. Dysregulation of neuropeptide signaling is also implicated in neurological disorders such as epilepsy. However, much is unknown about the mechanisms regulating specific neuropeptides to mediate behavior. Here, we report that the expression levels of dozens of neuropeptides are up-regulated in response to circuit activity imbalance in ...
In the general population, there is a strong association between having a seizure disorder and excess mortality. Waddy and colleagues examined epilepsy and seizures in a national end-stage kidney disease (ESKD) database. They found that having a diagnosis of epilepsy or seizures was 9-fold and 2-fold higher in patients with ESKD than in the general population. After adjusting for potential confounding variables, patients with ESKD and epilepsy or seizures were found to have an 11% and 14% increase in death compared with those patients with ESKD without either diagnosis.
Patients with end-stage renal disease requiring dialysis and persons with epilepsy are at increased risk of death. However, there is little information related to the risk of death when the 2 conditions co-exist. In this issue, Waddy et al. determined that among patients with end-stage renal disease, those with a diagnose of epilepsy or seizures have a higher risk of all-cause mortality compared with those who do not have an epilepsy or seizure diagnosis. This association was further modified by neurology consultation, with a low er risk in persons who had received a consultation.
Conclusion WS has an especially unfavorable prognosis: cerebral anomaly was confirmed in 89% of our patients. CP was present in almost two-thirds of the children with WS, most of them had severe cognitive and motor deficits. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
In status epilepticus the imperative to start anti-seizure therapy, initially subjugates the need to investigate the cause. Once treatment is initiated this balance shifts in favour of identifying: the causes and consequences of the seizure; the factors that predetermined the occurrence of status epilepticus; and finally the prognosis of this acute episode. Just as there are multiple causes of seizures and epilepsy, there are a vast number of causes of status epilepticus. We discuss the more common and the more important to identify as they may dictate a change in therapy or a certain prognosis.