Network Pharmacology Deciphering Mechanisms of Volatiles of Wendan Granule for the Treatment of Alzheimer's Disease.

Conclusion: The integrated network pharmacology method provides precise probe to illuminate the molecular mechanisms of the main volatiles of WDG for relieving senile dementia related syndromes, which will also facilitate the application of traditional Chinese medicine as an alternative or supplementary to conventional treatments of AD, as well as follow-up studies such as upgrading the quality standard of clinically applied herbal medicine and novel drug development. PMID: 30891080 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions Dysautonomic symptoms frequently occuring in α-synucleinopathies comprise cardiovascular, gastrointestinal, urogenital and thermoregulatory disturbances. These symptoms reduce quality of life and worsen prognosis. The understanding of their pathophysiology, as well as the detection of α-synuclein deposition and autonomic dysfunction in the premotor stages of α-synucleinopathies may be key for identifying novel treatment targets and improving clinical outcomes. While causative treatment is not yet available, improvement of quality of life can be achieved by personalized symptomatic treatment r...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model. Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokin...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
I’m a little dumb-founded whenever I run across a prescribing trend that goes against all of the available empirical evidence for common sense use of a medication. Nowhere is this more evident than with the prescription of atypical antipsychotic medications. It wouldn’t be too far a stretch to suggest that such prescriptions have become like Prozac prescriptions in the 1990s, the latest medication fad. But atypical antipsychotics, like Seroquel (quetiapine fumarate), are far more complex with far more problematic side effects than drugs like Prozac, and should only be prescribed for on-label use. The Washingto...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic General Medications Policy and Advocacy Adverse Effects Atypical Antipsychotic Bipolar Disorder Insomnia movement disorder Seroquel side effects Weight Gain Source Type: blogs
Statistics indicate as many as 24 percent of Alzheimer's patients wake up caregivers at night and have trouble sleeping.By Bob DeMarcoAlzheimer's Reading RoomRecently I received several emails about sleeping problems.Specifically, about Alzheimer's patients staying up at night, or Alzheimer's patients waking up the caregiver at night.Some doctors recommend antipsychotic medications for this problem.This is completely inappropriate and should be avoided. See -Antipsychotic Medications Linked to Increased Risk of Pneumonia in Alzheimer ’s Patients.Sleep Medications for Alzheimer's and Dementia PatientsStatistics indica...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care Alzheimer's Dementia alzheimer's sleep dementia care dementia help for caregivers family caregiving help alzheimer's help with dementia care memory care Source Type: blogs
Many of today’s most popular drugs can make you forgetful. They inhibit your brain’s chemical messengers. And this blocks your concentration, memory and ability to focus. More specifically, these drugs block the activity of a neurotransmitter in your brain called acetylcholine. Acetylcholine is directly involved in learning and memory. And blocking it is a risky business… I’ve seen confusion, memory loss, and declining mental skills in patients who take these drugs. New research confirms what I see in my own practice. One recent study found that people taking these kinds of drugs had shrunken ar...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Source Type: news
Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insom...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research
— Hundreds of companies around the globe, now including Elon Musk’s Neuralink and even Facebook,  are researching and developing new ways to help brain owners be smarter, sharper, and healthier. What explains this flurry of activity? Where may it be headed? To help you understand what’s going on, let me highlight five key facts that emerged from the recent SharpBrains Virtual Summit, where 200+ participants in 16 countries shared and discussed the latest about neurotech­nolo­gy, brain health and digital health.   Fact 1. There are 7.5 billion human brains out there, a...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology Akili Baycrest Brain-health BrainHQ Claritas Mindsciences Click Therapeutics cogmed Cogniciti cognifit digital health Educational Testing Service Elon Musk Facebook Headsp Source Type: blogs
Susan Schneider Williams, Robin Williams’ widow, wrote a devastating account of her husband’s final year of life before he died by suicide in 2014. An autopsy revealed that Robin Williams had Lewy body disease, an umbrella term used to describe both Parkinson’s disease dementia and dementia with Lewy bodies. In a letter this week addressed to neurologists, Susan described the “terrorist” who lived inside her husband’s brain and caused him to forget his movie lines, plagued him with delusions and paranoia, and engulfed him in fear, anxiety and depression. Her account of his medi...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Statistics indicate as many as 24 percent of Alzheimer's patients wake up caregivers at night.By Bob DeMarcoAlzheimer's Reading RoomRecently I received several emails about sleeping problems.Specifically, about Alzheimer's patients staying up at night, or Alzheimer's patients waking up the caregiver at night.Some doctors recommend antipsychotic medications for this problem. This is completely inappropriate and should be avoided. See -Antipsychotic Medications Linked to Increased Risk of Pneumonia in Alzheimer ’s Patients.Coping with Alzheimer'sStatistics indicate as many as 24 percent of Alzheimer's patients wake up ...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care Alzheimer's Dementia alzheimer's sleep dementia care dementia help for caregivers family caregiving help alzheimer's help with dementia care memory care Source Type: blogs
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