High-fructose corn syrup enhances intestinal tumor growth in mice

Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis.
Source: ScienceNOW - Category: Science Authors: Tags: Medicine, Diseases reports Source Type: news

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Objective The aims of the study were to evaluate the influence of level of spinal cord injury (SCI) on caloric intake relative to total daily energy expenditure (TDEE) and body composition, and to develop a SCI–specific correction factor for the TDEE estimation. Design Individuals with paraplegia (PARA, n = 28) and tetraplegia (TETRA, n = 13) were analyzed. Daily caloric intake, basal metabolic rate, and TDEE were obtained using dietary recall, indirect calorimetry, and prediction equations, respectively. Caloric intake and TDEE were adjusted to bodyweight. Body composition was assessed using dual-energy x-ray a...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles: CME Article . 2019 Series . Number 11 Source Type: research
Publication date: Available online 16 October 2019Source: Diagnostic and Interventional ImagingAuthor(s): E.M. Weisberg, L.C. Chu, S. Park, A.L. Yuille, K.W. Kinzler, B. Vogelstein, E.K. Fishman
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
Publication date: Available online 17 October 2019Source: European Journal of RadiologyAuthor(s): Said Pertuz, Antti Sassi, Kirsi Holli-Helenius, Joni Kamarainen, Irina Rinta-Kiikka, Anna-Leena Laaperi, Otso ArponenAbstractPurposeTo assess the association between breast cancer risk and mammographic parenchymal measures obtained using a fully-automated, publicly available software, OpenBreast.MethodsThis retrospective case-control study involved screening mammograms of asymptomatic women diagnosed with breast cancer between 2016 and 2017. The 114 cases were matched with corresponding healthy controls by birth and screening ...
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsThese results suggest that compared with PI-RADS v2, PI-RADS v2.1 could be preferable for evaluating TZ lesions.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies. PMID: 31621387 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Wang Q, Huang T, Ji J, Wang H, Guo C, Sun X, Zheng K, Dong Z, Cao Y Abstract Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials &methods: Total 358 patients enrolled were assigned into three (MLR-NLR 0, 1 and 2) groups per the cut-off values of MLR and NLR. Results: Kaplan-Meier curves showed MLR, NLR and their combination were statistically associated with DFS (p
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Gillis LJ Abstract Obesity is a major health issue. A community-based intervention was implemented on a college campus to help employees lose body weight and fat. Participants were scanned using the InBody device at pre- and post-intervention, measuring body weight, fat, and waist circumference. Participants attended 11 classes on healthy lifestyle education. A comparison of pre- and post-intervention measurements was made using a paired t-test, resulting in a statistically significant difference in outcome measures. Correlation between class attendance and pounds lost showed a moderate negative correlatio...
Source: Journal of Community Health Nursing - Category: Nursing Tags: J Community Health Nurs Source Type: research
CONCLUSIONS: Learning curve in RARC-iON has a significant impact on achievement of Trifecta. This tool combines accurate measurement of surgical proficiency with an independent predictive value in assessing 3-yr OS probabilities. PMID: 31619034 [PubMed - as supplied by publisher]
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
This study was carried out in accordance with the recommendations of the ethics standards defined by the EU legislation on the use of experimental animals (2010/63/EU) and Czech animal welfare act. The protocol was approved by the Institute of Microbiology animal care and use committee (approval ID: 85/2015 and 108/2016). Diets and Experimental Design In most experiments, shortly after weaning, the mice were switched either to animal protein-based diet—control (aCD, 176 g/kg crude protein; Cat# C1000) and high-protein diet (aHPD, 514 g/kg crude protein; Cat# C1001) or plant protein-based diet—control (pCD, 17...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we identified 37 genus-level core bacteria from feces of 101 healthy mice with different ages, sexes, and mouse strains in three previous studies. They collectively represented nearly half of the total sequences, and predominantly included carbohydrate- and amino acids-metabolizing bacteria and immunomodulatory bacteria. Among them, Anaerostipes indwelt the gut of all healthy mice. Co-abundance analysis showed that these core genera were clustered into five groups (Group C1–C5), which were ecologically related. For example, the abundances of Group C2 including probiotics Bifidobacterium and Lactobacill...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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