Red raspberry exhibits anti-metastatic properties against human nasopharyngeal carcinoma cells

(Natural News) A study published in The American Journal of Chinese Medicine suggested that red raspberry (Rubus idaeus) can be used to treat and prevent nasopharyngeal cancer. In the study, researchers at Chung Shan Medical University in China examined the antimetastatic properties of red raspberry extract on human nasopharyngeal carcinoma cells. Nasopharyngeal cancer is characterized...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news

Related Links:

Conditions:   Metastatic Nasopharyngeal Carcinoma;   Metastatic Nasopharyngeal Keratinizing Squamous Cell Carcinoma;   Metastatic Nasopharyngeal Undifferentiated Carcinoma;   Nasopharyngeal Nonkeratinizing Carcinoma;   Recurrent Nasopharyngeal Carcinoma;   Recurrent Nasopharyngeal Keratinizing Squa mous Cell Carcinoma;   Recurrent Nasopharyngeal Undifferentiated Carcinoma;   Stage IV Nasopharyngeal Carcinoma AJCC v8;   Stage IVA Nasopharyngeal Carcinoma AJCC v8;   Stage IVB Nasopharyng...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Dysregulated microRNAs (miRNAs) are involved in carcinoma progression, metastasis, and poor prognosis. We demonstrated that in nasopharyngeal carcinoma (NPC), transactivated MIR106A-5p promotes a malignant phenotype by functioning as a macroautophagy/autophagy suppressor by targeting BTG3 (BTG anti-proliferation factor 3) and activating autophagy-regulating MAPK signaling. MIR106A-5p expression was markedly increased in NPC cases based on quantitative real-time PCR, miRNA microarray, and TCGA database analysis findings. Moreover, MIR106A-5p was correlated with advanced stage, recurrence, and poor clinical...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
Nasopharyngeal carcinoma (NPC) has an unbalanced geographical distribution, with the highest incidence reported in Southeast Asia [1]. There were 129,000 new cases of NPC in 2018 [2] and approximately 70% of them were locoregionally advanced at diagnosis [3]. For patients with locoregionally advanced NPC (LANPC), concurrent chemoradiotherapy (CCRT) with or without induction chemotherapy (ICT) is recommended by the National Comprehensive Cancer Networkguidelines [4].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Conclusions: The MKK3-p38 axis represents a potential therapeutic target for capsaicin. MKK3 phosphorylation might serve as a biomarker to identify NPC patients most likely to benefit from adjunctive capsaicin treatment.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusions: Notably, the results suggested that 18F-FLT PET/CT could reflect the tumor boundaries more accurately than 18F-FDG PET/CT, MRI and CT, which makes 18F-FLT PET-CT more advantageous for the clinical delineation of the target volume in NPC.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Conclusion: LMP1 induced cell EMT via TGF-β/Smad3/NRP1 pathway, which promoted migration and invasion of NPC cells.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Conclusion: Our study provided evidence the first time that FOXA1 suppresses NPC cells via downregulation of miR-100-5p or miR-125b-5p.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
In this study, we explored the potential relationships among curcumin, circRNAs, and nasopharyngeal carcinoma (NPC). We compared the differences in circRNA levels in NPC cell lines after radiotherapy and after treatment with curcumin, using a high-throughput microarray. Further, a circRNA-miRNA-mRNA interaction network between radiation resistance NPC cell lines and tumor stem cells was constructed by applying bioinformatics. Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediatin...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Previous studies have implicated the important role of mesenchymal stem/stromal cells (MSCs) within tumor microenvironment (TME) in the pathogenesis and progression of nasopharyngeal carcinoma (NPC), but the potential mechanisms are still unclear. Herein, we showed that an elevated IL-6 level was positively correlated with elevated expression of CD73 in TME of NPC. NPC specimens with an IL-6highCD73high phenotype showed higher expression levels of gp80, gp130, p-STAT3, MMP-9 and α-SMA, and clinically, a poorer prognosis than those with an IL-6lowCD73low phenotype. We found that stimulation with conditioned media deri...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
OBJECTIVE: To analyze the pattern of local failure in patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT) and find a more reasonable delineation of the clinical target volume (CTV).METHODS AND MATERIALS: A total of 212 patients with non-metastatic NPC who underwent IMRT were analyzed. Radiation therapy was run at a total dose of 66-74 Gy (2.0-2.2 Gy fractions). The follow-up of local recurrence and the recurrence-related features were analyzed for the original treatment situation. The failures were delimited as “in-field failure” if Vrecur within the 95% isodose curve (V95...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | China Health | Health | Nasopharyngeal Cancer | Raspberries | Study