Studies show difficulty in treating type 2 diabetes in youth and highlight unique aspects of the disease in young people

New research reveals that the only two medications approved for pediatric type 2 diabetes do not prevent rapid progression of prediabetes or recent onset type 2 diabetes in young people with the disease; however, analyses comparing metabolic tests of adults in a companion study and the youth study participants are helping scientists understand how the disease differs with age, which may one day lead to better treatment approaches.
Source: NIDDK News - Category: Endocrinology Source Type: news

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DIABETES type 2 symptoms include unexplained weight loss, tiredness, and passing more urine than normal. But you could also be at risk of high blood sugar if you develop this unusual patch on your skin. Should you consider speaking to a doctor about diabetes symptoms?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This article provides practical guidance on the use of oral semaglutide in the primary care setting, based on evidence from clinical studies, including the phase 3a PIONEER program, and the authors' clinical experience. PMID: 32643514 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
ConclusionSlight changes in AUCinf, Cmax and CLR of metformin were observed when co-administered with peficitinib; however, these changes were considered not clinically relevant.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study used 30 adult male mice strain BALB/c. Diabetes was induced using high-fat diet/streptozotocin method until random blood glucose level reached> 200 mg/dL. Diabetic mice were then exposed to electrical field (static and dynamic), magnetic field (static and induce), and infrared ray (with or without infrared ray) combination therapy 15 min daily for 28 days. Fasting blood glucose level, plasma insulin level, HOMA-IR index, and membrane GLUT-4 density after treatment were analyzed statistically atα = 0.05. Result showed that exposure combination of electrical field, magnetic field, and infrared were found ...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
The objective of this study was investigating the additional effect of DL with nonsurgical periodontal treatment on the red complex bacteria in type 2 diabetes mellitus (DM) patients with chronic periodontitis (CP). Sixty type 2 DM patients with chronic periodontitis (CP) were randomly assigned in two parallel groups to receive scaling root planning (SRP,n = 30) or SRP followed by DL periodontal pocket irradiation (SRP + DL,n = 30). Recording of clinical parameters and subgingival plaque sampling were performed at baseline, and post therapy (1 and 3 months after treatment). Amounts ofPorphy...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
Condition:   Diabetes Mellitus, Type 2 Interventions:   Drug: JTT-662;   Drug: Placebo Sponsor:   Akros Pharma Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Healthy;   Type 2 Diabetes Interventions:   Biological: Saline;   Biological: Exendin-9,39;   Biological: Saline + Intralipid/Heparin;   Biological: Exendin-9,39 + Intralipid/Heparin Sponsors:   Adrian Vella;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Diabetes Mellitus, Type 2 Interventions:   Drug: JTT-662;   Drug: Placebo Sponsor:   Akros Pharma Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 10 July 2020Source: Canadian Journal of DiabetesAuthor(s): Yun-Ru Lai, Chih-Cheng Huang, Hsueh-Wen Chang, Wen-Chan Chiu, Nai-Wen Tsai, Ben-Chung Cheng, Jung-Fu Chen, Cheng-Hsien Lu
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
AbstractAims/hypothesisChronic stimulation of β2-adrenoceptors, opposite to acute treatment, was reported to reduce blood glucose levels, as well as to improve glucose and insulin tolerance in rodent models of diabetes by essentially unknown mechanisms. We recently described a novel pathway that mediates glucose uptake in skeletal muscle cells via stimulation of β2-adrenoceptors. In the current study we further explored the potential therapeutic relevance of β2-adrenoceptor stimulation to improve glucose homeostasis and the mechanisms responsible for the effect.MethodsC57Bl/6N mice with diet-induced obesity ...
Source: Diabetologia - Category: Endocrinology Source Type: research
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