Extracellular Vesicles in Lung Health, Disease, and Therapy: Mini-Review and Special Call for papers.

Extracellular Vesicles in Lung Health, Disease, and Therapy: Mini-Review and Special Call for papers. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 20;: Authors: McVey MJ, Maishan M, Blokland KEC, Bartlett N, Kuebler WM Abstract Both physiological homeostasis and pathological disease processes in the lung typically result from complex, yet coordinated multicellular responses which are synchronized via paracrine and endocrine intercellular communication pathways. Of late, extracellular vesicles have emerged as important information shuttles that can coordinate and disseminate homeostatic and disease signals. In parallel, extracellular vesicles in biological fluids such as sputum, mucus, epithelial lining fluid, edema fluid, the pulmonary circulation, pleural fluid, and lymphatics have emerged as promising candidate biomarkers for diagnosis and prognosis in lung disease. Extracellular vesicles are small sub-cellular membrane bound vesicles containing cargos from parent cells such as lipids, proteins, genetic information, or entire organelles. These cargos endow extracellular vesicles with biologically active information or functions by which they can reprogram their respective target cells. Recent studies show that extracellular vesicles found in lung-associated biological fluids play key roles as biomarkers and effectors of disease. Conversely, administration of naïve or engineered extracellular vesicles with homeostatic or reparative...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research