Nano-based approach to combat emerging viral (NIPAH virus) infection

Publication date: Available online 21 March 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Rout George Kerry, Santosh Malik, Yisehak Tsegaye Redda, Sabuj Sahoo, Jayanta Kumar Patra, Sanatan MajhiAbstractEmergence of new virus and their heterogeneity is growing at an alarming rate. Sudden outburst of Nipah virus (NiV) have raised serious question about their instant management using conventional medication and diagnostic measures. A coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. But in concurrent to resourceful and precise execution of nano-based medication, there is an ultimate need of concrete understanding of the NIV pathogenesis. Moreover, to amplify the effectiveness of nano-based approach in a conquest against NiV, a list of developed nanosystem with antiviral activity is also a prerequisite. Therefore the present review provides a meticulous cognizance of cellular and molecular pathogenesis of NiV. Conventional as well several nano-based diagnosis experimentations against viruses have been discussed. Lastly, potential efficacy of different forms of nano-based systems as convenient means to shield mankind against NiV has also been introduced.Graphical AbstractNipah virus (NiV) infects the host cell via cell surface receptor leading to the formation of syncitium, gradual degradation of which leads to the release of the virus in to b...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research