Neuroimmune Mechanisms of Latent Pain Sensitization after Chemotherapy

The episodic nature of chronic pain has been described in animal models as latent pain sensitization. For example, after remission from inflammatory or postsurgical pain, assessed by normalization of mechanical pain threshold, injection of opioid receptor inverse agonists reinstates allodynia (1,2,3). To investigate whether latent sensitization is also occurring in neuropathic pain and neuroimmune mechanisms are involved, male and female mice were treated with 3 daily injections of cisplatin (2 mg/kg) to induce a transient neuropathic pain.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research