Uncovering Cell-Specific Mechanisms in Sex Differences in TLR4-Dependent Pain

Uncovering how different cell types recognize and respond to danger-associated molecular patterns (DAMPs) could lead to new therapeutic insights and a better understanding of basic mechanisms of pain plasticity. Recent studies have bought  to light the necessity to discern sex-specific differences in various pain modalities and different cell-types that mediate these differences. These studies begin to uncover the role of neuroimmune interactions to mediate pain states in a sex-specific fashion. However, direct nociceptor activity a nd intrinsic properties in the context of immune action have not been at the forefront.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research