(128) Haplotype Analysis of COMT SNPs Associated with Pain Intensity and Acute Care Utilization in Adults with Sickle Cell Disease

Several COMT gene single nucleotide polymorphisms (SNPs) have been associated with pain and disability indicators in pain populations. Only one COMT SNP (rs4680) has been studied in patients with sickle cell disease (SCD) and found to be associated with pain-related acute care utilization but not with self-reported pain. Our aim was to examine the association among haplotypes of 14 other COMT SNPs with pain intensity and pain-related acute care utilization in SCD. Genetic and clinical data were collected on 130 (66% female, mean age 35.0+11.4 years, 76.2% Hemoglobin SS disease) individuals with SCD.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Molecular and Cellular Biology (with CE) Source Type: research