(194) Epidermal Axon Changes in Patients with Prediabetes: The PACMAN Study

Pain is a tremendous health care burden associated with prediabetes and diabetes. However, not everyone with prediabetes or diabetes develops pain and the factors that increase susceptibility to painful neuropathy remain elusive. The epidermis is innervated by both peptidergic and nonpeptidergic axons and our studies in mice reveal that mechanical allodynia induced by consuming a high fat diet increases peptidergic epidermal axons. We hypothesize that patients with prediabetes and painful neuropathy have an abnormal proportion of epidermal peptidergic axons.

Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: D. Wright, D. Elliott, M. Vitztum, J. Ryals, P. Kluding, M. Pasnoor Source Type: research