(224) An Open-Source Deep Neural Network to Assess Spontaneous Pain in Freely-Moving Mice using Facial Expressions

There is a dire need for new non-opioid analgesics. However, efforts to develop new pain medicines have thus far met with limited success. This failure is partly due to an overreliance on evoked pain measures in preclinical models. Most preclinical models  do not measure spontaneous pain—the main symptom of chronic pain in humans. Here we show our progress towards developing and validating a fully-automated and user-friendly spontaneous pain measurement tool by training a machine learning model to detect and quantify facial grimacing in mice.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research