(227) HIV Sensory Neuropathy Related Behaviors in Doxycycline Inducible HIV-1 Tat Transgenic Mice

Peripheral neuropathies are the most frequent neurological complications associated with HIV, within which HIV sensory neuropathy (SN) is the most common form, which affects 30-50% of HIV/acquired immunodeficiency syndrome (AIDS) patients. HIV SN is frequently manifested with hard-to-manage pain and is often under-diagnosed and/or under-treated. Tat, trans-activator of transcription, is a key activator of HIV transcription. Despite that recent studies have highlighted the role of HIV Tat in the pathophysiology of HIV-associated neurocognitive disorders (HANDs), the involvement of HIV Tat in neuropathic pain associated with HIV SN has not been extensively investigated.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research