(244) Development of Cephalic and Extra-Cephalic Tactile Allodynia in Two Models of Post-Traumatic Headache in Mice

Post-traumatic headache (PTH) after traumatic brain injury (TBI) is debilitating and hard to diagnose. Unfortunately, PTH is highly prevalent in active duty personnel, Veterans, as well as in sport athletes. The high incidence and chronic nature of PTH underscores the need to study these problems in animal models in order to develop new and effective treatments. The foundation of our study is the fact that PTH has many symptoms of chronic migraine. We proposed to evaluate photosensitivity and tactile hypersensitivity in two mouse models of mild TBI: the blast-induced TBI model and the closed-head injury (mCHI) model induced by weight drop.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research