(267) The Influence of Long-Term Western Diet and Voluntary Exercise in an Early Life Stress Mouse Model of Co-Morbid Disorders

Early life stress is associated with the development of chronic pain, mood, and obesity-related metabolic disorders in adulthood. Although the underlying mechanisms of these syndromes are unknown, altered regulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated. It is hypothesized that early life stress induces HPA axis dysfunction leading to the development of overlapping disorders. We have established a mouse model of early life stress, neonatal maternal separation (NMS), that displays molecular evidence of altered HPA axis regulation and urogenital hypersensitivity and dysfunction, which can be mitigated by voluntary exercise.

Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: O. Eller-Smith, X. Yang, E. Morris, J. Thyfault, J. Christianson Source Type: research