(406) Comparative Effectiveness of CL-108 and Ibuprofen for Acute Postoperative Pain

Comparative effectiveness studies can provide clinically meaningful and useful evidence of drug performance. The comparative effectiveness of ibuprofen and CL-108 (hydro-codone 7.5 mg/acetaminophen 325 mg/low-dose promethazine 12.5 mg) for acute postoperative pain was examined post hoc when it was noted that all patients in the placebo treatment group in a randomized controlled trial1 had used multiple doses of ibuprofen as needed throughout the 48-hour treatment evaluation period. Pharmacologically, these were ibuprofen-treated patients.

Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: T. Gan, B. Schachtel, B. Zhang Source Type: research