Association of Listeria monocytogenes LIPI-1 and LIPI-3 marker llsX with invasiveness.

Association of Listeria monocytogenes LIPI-1 and LIPI-3 marker llsX with invasiveness. Curr Microbiol. 2019 Mar 19;: Authors: Vilchis-Rangel RE, Espinoza-Mellado MDR, Salinas-Jaramillo IJ, Martinez-Peña MD, Rodas-Suárez OR Abstract Listeria monocytogenes is an opportunistic pathogen that is widely distributed in the environment. The evolution of its genome has exhibited differences in virulence among strains of the same species. Listeria monocytogenes LIPI-3 (Listeria Pathogenicity Island 3) and LIPI-1 (Listeria Pathogenicity Island 1) are considered responsible for the increased virulence in some strains. The aim of this study was to detect LIPI-1 genes and the llsX gene belonging to LIPI-3 in invasive strains of L. monocytogenes and to establish whether there is a relationship among the invasiveness, presence of the llsX and LIPI-1 genes, and the source of the strains. The results showed that 70% of the strains were invasive, and all these strains except one possessed LIPI-1, which suggests that although there is a correlation between LIPI-1 and invasiveness, the independent mechanisms of LIPI-1 may contribute to invasiveness. In contrast, 35% of the total strains were positive for llsX and were invasive; thus, the results revealed that there is a strong association between llsX and the invasiveness of L. monocytogenes in HEp-2 cells (HeLa contaminant/epithelial in origin). In addition, there is no other association with any othe...
Source: Current Microbiology - Category: Microbiology Authors: Tags: Curr Microbiol Source Type: research