Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice

Publication date: Available online 20 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Raquell de Castro Chaves, Auriana Serra Vasconcelos Mallmann, Natália Ferreira Oliveira, Iris Cristina Maia Oliveira, Victor Celso Cavalcanti Capibaribe, Daniel Moreira Alves da Silva, Iardja Stéfane Lopes, José Tiago Valentim, Alyne Mara Rodrigues de Carvalho, Danielle Silveira Macêdo, Silvânia Maria Mendes Vasconcelos, Stanley Juan Chaves Gutierrez, José Maria Barbosa Filho, Francisca Cléa Florenço de SousaAbstractMental disorders have a multifactorial etiology and stress presents as one of the causal factors. In depression, it is suggested that high cortisol concentration contributes directly to the pathology of this disease. Based on that, the study aims to evaluate the potential antidepressant effect of Riparin IV (Rip IV) in mice submitted to chronic stress model by repeated corticosterone administration. Female Swiss mice were selected into four groups: control (Ctrl), corticosterone (Cort), Riparin IV (Cort + Rip IV) and fluvoxamine (Cort + Flu). Three groups were administrated subcutaneously (SC) with corticosterone (20 mg/kg) during twenty-one days, while the control group received only vehicle. After the fourteenth day, groups were administrated tested drugs: Riparin IV, fluvoxamine or distilled water, by gavage, 1 h after subcutaneous injections. After the final treatment, animals were exposed to behavioral models such as forced swimming tes...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research