The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

In mice, the initial stage of nephrotoxic serum-induced nephritis (NTN) mimics antibody-mediated human glomerulonephritis. Local immune deposits generate tumor necrosis factor (TNF), which activates pro-inflammatory pathways in glomerular endothelial cells (GECs) and podocytes. Because TNF receptors mediate antibacterial defense, existing anti-TNF therapies can promote infection; however, we have previously demonstrated that different functional domains of TNF may have opposing effects. The TIP peptide  mimics the lectin-like domain of TNF, and has been shown to blunt inflammation in acute lung injury without impairing TNF receptor-mediated antibacterial activity.

Source: Kidney International - March 19, 2019 Category: Urology & Nephrology Authors: Michael P. Madaio, Istvan Czikora, Nino Kvirkvelia, Malgorzata McMenamin, Qiang Yue, Ting Liu, Haroldo A. Toque, Supriya Sridhar, Katherine Covington, Rabei Alaisami, Paul M. O ’Connor, Robert W. Caldwell, Jian-Kang Chen, Matthias Clauss, Michael W. Bra Tags: Basic Research Source Type: research