Protein BRCA1 as a stress coach

(University of W ü rzburg) Two proteins work hand in hand to ensure that the tumor cells of neuroblastoma can grow at full speed. In Nature, a W ü rzburg research team shows how the proteins can do this.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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This study distinguished hub genes and related signaling pathways that can potentially serve as diagnostic indicators and therapeutic biomarkers for NB, thereby improving understanding of the molecular mechanisms involved in NB.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Conditions:   Constitutional Mismatch Repair Deficiency Syndrome;   Hematopoietic and Lymphoid Cell Neoplasm;   Lynch Syndrome;   Recurrent Lymphoma;   Recurrent Malignant Solid Neoplasm;   Recurrent Neuroblastoma;   Recurrent Primary Central Nervous System Neoplasm;   Refractory Lympho ma;   Refractory Malignant Solid Neoplasm;   Refractory Neuroblastoma;   Refractory Primary Central Nervous System Neoplasm;   Xeroderma Pigmentosum Interventions:   Proced...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In the October 2018 issue of International Journal of Clinical Oncology.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
             Basel, 03 August 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the European Commission has granted conditional marketing authorisation for Rozlytrek®(entrectinib) for the treatment of adult and paediatric patients 12 years of age and older with solid tumours expressing a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and who have not received a prior NTRK inhibitor, who have no satisfactory t...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
Authors: Licitra L, Resteghini C, Bossi P Abstract The inclusion of systemic therapy in the multimodal approach of locally advanced sinonasal cancers, at least in some selected histologies, may improve locoregional control and reduce the frequency of distant metastasis, allowing longer survival. Response to induction chemotherapy is a strong prognostic factor for a patient's outcome and it may improve disease control by surgery and radiation. Concurrent chemoradiation aims at increasing locoregional control in squamous cell cancer of the head and neck; this is particularly important in sinonasal cancers, with a ris...
Source: Advances in Oto-Rhino-Laryngology - Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Contributors : Evon Poon ; Louis CheslerSeries Type : Expression profiling by arrayOrganism : Homo sapiens ; Mus musculusNeuroblastoma is a common solid tumor that accounts for 15% of cancer deaths in children and amplification of the MYCN oncogene is the most common genomic alteration in aggressive tumors. Although MYCN is expressed as a tumor-specific oncoprotein in poor-outcome neuroblastoma, making it a therapeutic target of great potential importance, no drugs with significant activity against MYCN or MYC are available for clinical use. The aim of this study was to explore the sensitivity of neuroblastoma cells in vit...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Mus musculus Source Type: research
Background: The optimal choice of initial antibiotic therapy for patients with high-risk febrile neutropenia (FN) in children is unclear and varies by the institution on the basis of local antibiograms and epidemiology of specific pathogens. The authors evaluated the appropriateness of antibiotics for the empiric treatment of FN in pediatric patients with cancer in our institution on the basis of changes in the epidemiology of organisms isolated from blood cultures (BCx). Methods: The authors conducted a retrospective medical record review of pediatric patients who received any oncology care (including patients with c...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Original Articles Source Type: research
Authors: Illendula A, Fultang N, Peethambaran B Abstract Neuroblastoma is the most common inheritable, solid neoplasm in children found under the age of 7 and accounts for approximately 7% of childhood cancers. A common treatment that has been prescribed for over a decade is retinoid therapy [using all‑trans retinoic acid (RA)]. Treatment with this differentiating agent has been revealed to progress the cells from their stem‑cell state to a mature neuronal state gaining classical neuronal characteristics, including the suppression of proliferation. However, the molecular mechanism underlying the action of RA tr...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Contributors : Florida Voli ; Emanuele Valli ; Luigi Lerra ; Kathleen Kimpton ; Federica Saletta ; Federico M Giorgi ; Daniele Mercatelli ; Jourdin R Rouaen ; Sylvie Shen ; Jayne E Murray ; Aria Ahmed-Cox ; Giuseppe Cirillo ; Chelsea Mayoh ; Paul A Beavis ; Michelle Haber ; Joseph A Trapani ; Maria Kavallaris ; Orazio VittorioSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTherapeutic checkpoint antibodies blocking PD1/PD-L1 signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly understood. Here we show...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Rongling Wu Neuroblastoma is a common cancer in children, affected by a number of genes that interact with each other through intricate but coordinated networks. Traditional approaches can only reconstruct a single regulatory network that is topologically not informative enough to explain the complexity of neuroblastoma risk. We implemented and modified an advanced model for recovering informative, omnidirectional, dynamic, and personalized networks (idopNetworks) from static gene expression data for neuroblastoma risk. We analyzed 3439 immune genes of neuroblastoma for 217 high-risk patients and 30 low-risk patients...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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