Chloride Channel Accessory 4 (CLCA4) Gene Polymorphisms and Non-Obstructive Azoospermia: A Case-Control Study.

CONCLUSIONS There were no significant associations between CLCA4 SNPs and NOA in men in a Chinese Han population of Northeast China. PMID: 30887952 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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CONCLUSION: Neither Arg194Trp nor Arg399Gln polymorphisms in the XRCC1 gene influenced risk of INOA in our study. However, these findings may be helpful in improving the understanding of the etiology of male infertility. PMID: 31004343 [PubMed - as supplied by publisher]
Source: Urology Journal - Category: Urology & Nephrology Authors: Tags: Urol J Source Type: research
ConclusionsThe application of HLA*PRG:LA tool to the study of male infertility provided novel insights for anHLA correlation with semen quality, namely among SHV and OLI phenotypes. The discovery of anHLA ‐A*29:02/HPV crosstalk, together with former reports ofHLA alleles conferring resistance –susceptibility to diverse human pathogens, raises the hypothesis of a mechanistic link between male infertility,HLA polymorphism, and host response to STD.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Conclusion The periconceptional environment and lifestyle factors modify sperm epigenome. This alteration might be maintained in the zygote and throughout development, thereby leading to the inheritance of newly acquired pathologies. The role of sperm miRNA, not only as innovative markers of fertility issues but also as vectors involved in the inheritance of paternal diseases, appears to be crucial. Overweight and obesity seem to alter sperm miRNA profile, thereby leading to transmission of different miRNA profiles in zygote, with consequences on embryo development. In long term, metabolic disorders have been described in...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Authors: Cho CL, Esteves SC, Agarwal A Abstract Varicoceles exert deleterious effect on testicular function. The condition has been associated with male infertility, testicular hypotrophy and pain. These comprises the common indications for varicocele repair currently. Significant improvement in semen parameters and pregnancy outcomes had been suggested by reports decades ago. However, selection of the best candidates remains an issue since not all patients respond positively to treatment. Consensus has been reached in recent decade after the publication of a series of meta-analyses. Significant improvement in preg...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Conclusion We have identified a rich and complex sperm transcriptome with known and novel coding RNAs, lncRNAs and sncRNAs that resembles the human, mouse and cattle counterparts. Their roles are mainly related to the regulation of spermatogenesis, fertility and early embryo development. These spermatozoal transcripts are fragmented, likely in a selective manner, consistently affecting some genes more than others across samples. This suggests that their fragmentation is not stochastic and follows an unknown deterministic pattern with potential functional implications. Similarly, the variability of the transcript abundance...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Abstract MicroRNAs (miRNAs) have recently been shown to be important for spermatogenesis; both DROSHA and Dicer1 KO mice exhibit infertility due to abnormal miRNA expression. However, the roles of individual miRNAs in spermatogenesis remain elusive. Here we demonstrated that miR-15b, a member of the miR-15/16 family, is primarily expressed in testis. A miR-15b transgenic mouse model was constructed to investigate the role of miR-15b in spermatogenesis. Impaired spermatogenesis was observed in miR-15b transgenic mice, suggesting that appropriate expression of miR-15b is vital for spermatogenesis. Furthermore, we de...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
Rationale: Y;autosome translocations are associated with male infertility and azoospermia. Some carriers with a Y:22 translocation can produce offspring and transmit the translocation through generations without phenotypic repercussion. Hence, the clinical features of carriers with certain Y chromosome abnormalities remain uncertain. Patient concerns: An apparently healthy 33-year-old man, 175 cm tall and weighing 60 kg had a 6-month history of primary infertility. Diagnoses: The patient was diagnosed with oligoasthenozoospermia. A series of examinations have been performed to evaluate possible genetic causes o...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
The most severe form of male infertility, non-obstructive azoospermia (NOA), is a lack of sperm in the ejaculate with very little to no sperm production in the seminiferous tubules. Non-obstructive azoospermia accounts for 10% of male infertility cases because the sperm are rare in NOA patients, identification and collection of these cells are inefficient, costly, and time consuming. The field of artificial intelligence (AI) provides opportunities for many needs in cell biology, but is particularly powerful when considering applications in low cell number analyses/identification.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster Presentation Source Type: research
CONCLUSION: Based on identified interactome, it is plausible that HE4 plays a crucial role in fertilization, specifically in sperm maturation, motility and capacitation. PMID: 30919767 [PubMed - as supplied by publisher]
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research
AbstractUbiquitin-specific protease 26 (USP26) is a deubiquitylating enzyme belonging to the USPs family with a transcription pattern restricted to the male germline. Since protein ubiquitination is an essential regulatory mechanism during meiosis, many efforts have been focused on elucidating the function of USP26 and its relationship with fertility. During the last decade, several studies have reported the presence of different polymorphisms inUSP26 in patients with non-obstructive azoospermia (NOA) or severe oligozoospermia suggesting that this gene may be associated with human infertility. However, other studies have r...
Source: Chromosoma - Category: Genetics & Stem Cells Source Type: research
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